I was thinking about trying supplements against depression and there are a few ones which sound interesting like L-Theanine, 5-HTP, Sam-E, Inositol.
But the thing is that in contrast to drugs they do not have a leaflet which tellls you all possible side effects and drug interactions. I'd rather take something which can have a few side effects and where I at least know which side effects exist and what interactions with other drugs exist than to take a supplement and then have no clue what might happen or if it could be combined with drugs or not. This is a huge disadvantage.
For example what do I do if I try a supplement which really seems to work but then I also a tranquilizer or something else? Then who could tell me if I can take a tranquilizer or not because it could interfere with the supplement?
Usually doctors don't know much about supplements and probably also couldn't tell if a supplement could be combined with a benzo or SSRI.
Even if I found a supplement which really worked then it would still worry me if I did not know what would happen in a situation where I needed to take a benzo against acute anxiety or another drug like a betablocker or an antibiotic. Just because something is sold as supplement doesn't mean it's safe and has no interactions or side effects. :(