This has been the worst day for me so far. I am on day six of starting duloxetine. Early this morning I got up to go to the loo and could barely navigate myself there and back. It felt as if I was drunk but I haven't taken any alcohol. I cut that out at the beginning because I thought it wasn't helping. Today has been the worst day of the week symptom wise. I have felt completly out of it and so tired so much so I had a sleep at lunch time. I'm hoping that these symptoms will ease next week. I just cant afford to be spaced out at work. The giddiness in the morning is difficult to contend with. It improves if I sit up in bed for a little while. Hopefully these symptoms will improve as my body gets used to the duloxetine. It is not good at the moment. Hopefully I can stick with it.