I've been on effexor about 8 years now (75mg). Im wondering if anyone else has been on them this long or longer, and if they noticed any changes in side effects over time? I tried to come off them 2 years ago and almost went insane with withdrawal symptoms so i've kind of resigned myself to staying on them for the forseeable future and my doctor doesnt seem to mind. Lately i've been getting really tired. i'm 26 but often feel drained after doing very little. A lot more now than I used to. Tiredness is a big side effect of these meds for me. Sometimes now I almost feel the "brain zaps" that I got during the times I was trying to come off it even though I havent changed the dose. Just wondering if anyone else has any long term use side effect stories as most people here seem to be only on it short periods???