pharmaceutical industry and their 'reinventions'

[Meilo]

There is a certain irony here:

"Ugh, tricyclics! Low selectivity for the serotonin transporter over the noradrenaline transporter, and what's with all the antagonism at histamine, alpha and 5HT2A receptors? Dirty stuff! Thankfully this is the 90's, and we have Selective Serotonin Reuptake Inhibitors!"

"...eh, maybe you do need a bit of a noradrenaline boost on top. Thankfully this is 2000, and we have SNRI's!"

"...and maybe it would be nice to have some histamine/5HT2-antagonism-mediated anti-anxiety action, too. It's 2010, try some Seroquel or Mirtazapine on top of your antidepressant!"

"...and we do want some alpha1-adrenergic receptor antagonism to normalize the HPA axis! And some FIASMA / BDNF would be nice. R&D, get started! It's 2018!"

"...or just have a tricyclic."



I would not be surprised if they try to market anticholinergics as new groundbreaking anxiolytics in a few years from now...

[KK77]

Very clever and perceptive. And (sadly) true

[Meilo]

Very clever and perceptive. And (sadly) true

Indeed

[KK77]

Indeed

So what is your story? Tell us a bit about yourself...

[MyNameIsTerry]

And we come back around to TCA's coming out in clinical testing as more efficient

The SNRI class is a bit of an odd one. Ven is so inefficient for the N that Sertraline is far more potent instead so we already had it in a way.

Histamine is the next one. That may have some use though considering how ramping up that will make your mind bounce off the walls.

I reckon they will keep pushing the anti epilepsy drugs too.

[Meilo]

So what is your story? Tell us a bit about yourself...

It's the same old story all over again ^^

SAD and depression => SSRI => Zombie => second SSRI => SSRI carousel... => **** this shit, I am going home...

Those pdocs with their stupid SSRIs
I am trying to get my hands on a tricyclic (Clomipramine)

---------- Post added at 23:14 ---------- Previous post was at 23:14 ----------

I reckon they will keep pushing the anti epilepsy drugs too.

Yes, they are getting very "popular".