Pregabalin with Sertraline?

[Dazza123]

I have been on Pregab for a while now (again) 2x150mg daily, but apart from feeling like its a bit too much for me, I have been putting on weight for no reason, and have also been feeling quite down and low, so had a chat with the doctor today (45 minutes) and we decided to drop down to 2x75mg daily and to add 50mg of Sertraline.

I just wonder what to expect from this, the drop in Pregab will be ok for me as I have dropped before with no bad experience, but not sure what happens when the AD is added into the mix.

I am hoping its a good thing?

[heather89]

I think this could be a good mix. I was on sertraline right before I started pregabalin and it was going well for me but the dry mouth got really bad for me and caused sores in my mouth. I think this was due to the fact I was on roaccutane in the past which tends to give me long terms dry skin and mouth. I would love to be on both sertraline and pregabalin. I think it is Defo worth a shot. Best of luck!

[hanshan]

I haven't tried sertraline, but I take pregabalin and mirtazapine, and find the combination of pregabalin plus an AD works well for me. Good luck with pregabalin plus sertraline, and as others have posted, it may need a few weeks to work.

[Dazza123]

Thanks for the replies :) I have woken feeling very dry and a bit spacey, but not to bad at the minute which is good. I think its a good combo so fingers crossed it will perk me up a bit. One thing I had noticed on just pregabalin was that I was feeling quite depressed, so not sure if thats one of its effects.

I certainly feel like I have taken something else today as I take the sertraline at night so definitely feel different, but not a bad different so here's hoping :)

[cristine]

Interesting what you were saying about feeling depressed I recently came off pregabalin and found myself sinking into depression couldn't get a doctors appointment for two weeks so started up the pregabalin again which lifted it !! ?? :-/

[Dazza123]

Its funny how these meds affect us all so differently isnt it, id love to know how and why that happens. I feel perkier today, but not quite me, its all good so far though so I wont complain :)

[MyNameIsTerry]

Its funny how these meds affect us all so differently isnt it, id love to know how and why that happens.

So would the medical community :winks::D

[KK77]

I was on Sertraline/Pregabalin combo for a few years until Sert stopped working. Felt depression was creeping back and I increased to 150mg. However, I found it mild side effect-wise with only a transient increase in anxiety and night sweats, which passed after a couple of weeks. I'm on Venlafaxine now which seems to control depression much better, albeit with more side effects than Sert.

Hope that helps.

[Dazza123]

So would the medical community :winks::D

It can only be chemicals in the brain that make a difference I assume, what do you think Terry?

Not feeling too bad today, been in the garden all day doing stuff so now I have achey back, I am certainly focusing a lot more. I usually drift around looking at what I have and whats happening, but today it was planting time and thats all I did, no wandering off.

KK - I can't say I really get side effects from Sertraline, I obviously don't feel myself on them, maybe a bit more aware, but nothing bad so far...:wacko:

[SarahH]

I take pregabalin and Citalopram which works well for me:)

sarah

[Dazza123]

Hi Sarah,

Yeah I think, after trying pregabalin on a few occassions that it clearly needs an AD for other issues, and so far they are working ok together, I dont feel too bad at all. I have the odd half hour where I am a bit anxious, or feel slightly manic etc but nothing terrible. It will change as they settle I know, so hoping it just stays steady for me :)

[MyNameIsTerry]

It can only be chemicals in the brain that make a difference I assume, what do you think Terry?

Not feeling too bad today, been in the garden all day doing stuff so now I have achey back, I am certainly focusing a lot more. I usually drift around looking at what I have and whats happening, but today it was planting time and thats all I did, no wandering off.



I guess so. I think I read something somewhere about the possibility of some people having certain receptors that are more sensitive, so maybe that too? I guess there is also the question of how much is missing out of the tank, some people might need a bigger boost to restore their chemicals.

With the amount of work you will be doing in your garden Dazza, the heron won't get a look in! :winks::D

[Dazza123]

Well things are going well so far, I feel like I am buzzing a bit internally today which is probably the sertraline, this could set me off into a bit of a panic normally but the pregabalin is probably stopping that. I do not like being on meds at all, especially a combination of 2, but I am hoping that once it settles it could be good. I definitely feel brighter which is unusual and I actually feel like getting off my backside today and doing more stuff, not been like this for a long time - maybe its time to tackle the bindweed :scared15:

The Heron hasn't been back to my knowledge, and I do keep an eye out there, this is odd because they always always come back, the good thing is I am not waking up at the crack of dawn now and staring out of the window looking for it - I'll thank the medication for that :)

[hanshan]

Genetically, I think both the quantity and type of receptors in the brain varies from person to person. And of course, upbringing and all the learning it involves affects how all the neurons in the brain are connected.

So each person's brain, though vastly the same in many ways as other people's, is also a unique patch of territory with its own individual responses.