Is there a serotonin only TCA?

[Jakemje]

After 4 different meds that act on serotonin "and" norepinephrine, my doc has come to the conclusion that my brain can't handle and adjustments to adrenaline. Is there a TCA that doesn't mess with norepinephrine in any way? Basically just and older SSRI? (I have tried all of the ssri's and they have worked till they pooped out)

[Duckbruck]

After 4 different meds that act on serotonin "and" norepinephrine, my doc has come to the conclusion that my brain can't handle and adjustments to adrenaline. Is there a TCA that doesn't mess with norepinephrine in any way? Basically just and older SSRI? (I have tried all of the ssri's and they have worked till they pooped out)

What meds were those?

---------- Post added at 15:57 ---------- Previous post was at 15:50 ----------

hmmm... only Serotonin... that's difficult.
Next best things would be Trimipramine and Amitriptyline. Amitriptyline has Nortriptyline as an active metabolite, but overall it should feel "sertoniny".

https://en.wikipedia.org/wiki/Trimipramine
https://en.wikipedia.org/wiki/Amitriptyline

---------- Post added at 16:00 ---------- Previous post was at 15:57 ----------

You might wanna try high dosed Trazodone
https://en.wikipedia.org/wiki/Trazodone

---------- Post added at 16:02 ---------- Previous post was at 16:00 ----------

Did you try Vortioxetine (Brintellix | Trintellix) or Venlafaxine (Effexor)?

https://en.wikipedia.org/wiki/Venlafaxine
https://en.wikipedia.org/wiki/Vortioxetine

[Jakemje]

I have tried effexor, anafranil, Elavil, and cymbalta. They all effect norepinephrine. Before that for just an ssri, I have been on lexapro, paxil, Zoloft, and Prozac.

The only meds that have actually worked was the lexapro and Prozac till they pooped out. The snri's was after the ssri's and then TCAs.

Anything I take that effects my adrenaline sends my body in to a freak out.

[Duckbruck]

I have tried effexor, anafranil, Elavil, and cymbalta. They all effect norepinephrine. Before that for just an ssri, I have been on lexapro, paxil, Zoloft, and Prozac.

Effexor (Venlafaxine) is an SSRI. The "SNRI" label is just marketing.
Try Trimipramine. It only has a very weak NORT binding. It's the "purest" TCA-SRI available.

---------- Post added at 17:42 ---------- Previous post was at 17:39 ----------

btw.: MAOI (Parnate, Nardil) might be worth a try. They have some adrenergic action, but they work differently than typical reuptake inhibitors... and feel differently. And are much more efficient than newer antidepressants and anxiolytics.

http://psychotropical.info/