No More Panic > Blog > Mirtazapine (Zispin)

Mirtazapine (Zispin)

Mirtazapine (Zispin)

No More Panic forum posts about this medication can be found here: Zispin / Mirtazapine

Mirtazapine is a type of antidepressant medicine. It works by enhancing the activity of neurotransmitters called noradrenaline and serotonin in the brain.

Benefits Seen

  • It can take between two to four weeks before it starts to work, so it’s very important that you keep taking it, even if it doesn’t seem to help at first. You’ll usually need to keep taking Mirtazapine every day for several months, and for at least six months after you feel better.

If Stop Taking

  • Do not stop without consulting your doctor
  • Wean off slowly


  • Do not take this drug if you have taken the MAOI antidepressants phenelzine, tranylcypromine, isocarboxazid, or moclobemide in the last 14 days.
  • Do not take this drug if you are under 18 years of age.

Do not use if

  • Mirtazapine tablets that dissolve on the tongue may contain aspartame, which is a source of phenylalanine. For this reason, they may not be suitable for people with an inherited disorder of protein metabolism called phenylketonuria.

Inform your Doctor if

  • You are pregnant, wanting to get pregnant or breast-feeding.
  • You have a history of bipolar affective disorder (manic depression).
  • You have a psychotic illness such as schizophrenia.
  • You have kidney or liver problems.
  • You have heart disease, e.g. irregular heartbeats (arrhythmias), angina or a recent heart attack.

Symptoms or Side Effects



See doctor always

See doctor if severe

See doctor NOW