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I never noticed if I missed one 75mg dose, only if I missed a few in a row, but since going up I notice an upset stomach and nausea within 12 hours. Is it normal for these effects to happen this quickly? Even on the modified release version?
Yes, withdrawal symptoms can happen that quickly, even sooner for some. Venlafaxine's half-life is only 5 hours +/- 2 hours so there's often not much left in the 'tank' at the end of 24 hours. Even when taken regularly people report doing better when they take it as a split dose presumably because blood plasma levels are then more stable.