Dosage Increase

Hello guys,

This would be my second post on these forums. I'm currently on a relapse of anxiety, GAD to be exact. Its been about a month. Before that I took Cymbalta 30mg every day and managed perfectly. Due to this relapse my Psychiatrist increased my dosage to 60mg a day. My question is, how long will it take for the dosage increase to take effect? It's been about two weeks now at 60mg and things are so so. Also, when the dosage is increased does it bring the counter back to cero, meaning is it like starting all over again having to wait 4 to six weeks for the med to kick in?

Any input will be greatly appreciated.

Take care.

Hey Howdy, I would imagine it's hard to say when things will improve. When did you notice things getting better on the 30mg? They say 6-8 weeks at a dose before you can say if it's working so 2 weeks isn't long and they will still be building in your system. I started on 20mg 4 weeks ago and they have helped, just need a bit more so I started 30mg 2 days ago and have some side effects back. My doctor wants to see me after 4 weeks to evaluate.

I think 2 weeks is a bit early to judge on the 60mg I would give it another 2 weeks and see how your doing.

Thanks for the response Jem! Acutally I took 30mg for years and worked fine. I started stopping it like a 2 months ago because I was doing fine (took one dose every 2 days until stopping completely), but that didn't work obviously... So I restarted again at 30mgs and my doc upped my dosage to 60mg.

Since my relapse I was on 30mg for about 2 weeks and now 2 weeks at 60mg.

hello first time posting, I have been on 20 mg for 8 weeks, I felt better after about 6, now I feel the same as I did before taking them, I was thinking about increasing to 30 mgs myself? any thoughts

Hey guys, Howdy I reckon it could be another week or two... You've only been on the 60mg for two weeks so still time yet to see an improvement. My doc always evaluates at 4 weeks although I know some say 6-8 weeks.

Jonny, my doc also told me that 30mg was a starting dose although some people do well and stay on that and that 60mg is the therapeutic dose but we all react differently. He started me on 20mg because I'm really sensitive to meds and I get bad side effects, he always planned to put me up to 30mg after the 4 weeks. Been on the 30 for 2 days so can't really advise what to expect but if you are still not feeling right then I'd go back and see your doctor and see if he suggests an increase.

Ok ok, hopefully It'll kick in soon this med has always worked before and brings me back to normal. I'm also taking 150mg of Lyrica (75mg am and 75pm) with 1mg of clonazepam and 25mg of quetiapine before going to bed.

I could've sworn I was over this! Until last month or so I was only taking 1mg clonazepman, 30mg of Cymbalta and I was going great. Oh well, I'll just have to push on and hold my crap together :(

How are you getting on Howdy?

Hello Jem,

Well I have to say that the weekend has been going fine, although I haven't had any stressors really. Other than that, what I believe is helping me the most is the Lyrica. Here's hoping that the 60mg of Cymbalta kicks in soon as ADs are the ones that actually "cure" the condition (at least in my experience).

Hi.I'm new to this. I suffer with MADD (Mixed anxiety and depressive disorder). I've recently changed from Sertraline, which was fabulous for a couple of years to 60 mgs Duloxetine and I'm really struggling on it. I now take Quetiapine 50mgs as well as 450mgs Pregabalin.

Has anyone had any success on Duloxetine?

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Originally Posted by fergie752uk

Hi.I'm new to this.

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Welcome to No More Panic, :welcome:

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I suffer with MADD (Mixed anxiety and depressive disorder). I've recently changed from Sertraline, which was fabulous for a couple of years

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I assume sertraline was no longer working. How much were you taking when it quit?

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to 60 mgs Duloxetine and I'm really struggling on it. I now take Quetiapine 50mgs as well as 450mgs Pregabalin.

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How long have you been on duloxetine, and when were quetiapine and pregabalin added, and why?

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Has anyone had any success on Duloxetine?

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Duloxetine is the pick of the SNRIs which are usually slightly more effective than the SSRIs and less likely to stop working than them too. There is a very good chance duloxetine will work for you, but there are no guarantees. Because of the way they work, antidepressant effectiveness depends on how well the drug meshes with individual biology. More so than is the case with almost all other types of meds.

Hiya.

To answer your questions I was put on 40 mgs Citalopram and 450 mgs Pregabalin in 2014 after suddenly suffering panic attacks.

I then switched to Sertraline 200mgs which was fab for a long while but then I just began to slide down very slowly.

I started taking Duloxetine on 26th December last year. Started on 30 mgs and upped to 60 now but still not feeling the love so the Quetiepine has been introduced and I have been referred for psychological counselling as my med prescriber thinks I may be suffering from complicated grief disorder. I have an appointment on Monday for that and a med review on 24/04 but I have called and left a message for my prescriber as I don't think I can stand myself for that long.

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Originally Posted by fergie752uk

To answer your questions I was put on 40 mgs Citalopram and 450 mgs Pregabalin in 2014 after suddenly suffering panic attacks.

I then switched to Sertraline 200mgs which was fab for a long while but then I just began to slide down very slowly.

I started taking Duloxetine on 26th December last year. Started on 30 mgs and upped to 60 now but still not feeling the love so the Quetiepine has been introduced

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Given you've needed to take the maximum doses of the two previous antidepressants to achieve a good result increasing the duloxetine dose up to the maximum 120mg would have been better than adding the quetiapine, imho. Some of us, e.g. me, need a lot of antidepressant to get a worthwhile response.

For some reason I can't fathom, it has become the fashion lately to throw an antipsychotic into the med mix at the first hint an antidepressant isn't working even while at low doses. Imho, it should be the very last thing tried.

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Originally Posted by panic_down_under

Given you've needed to take the maximum doses of the two previous antidepressants to achieve a good result increasing the duloxetine dose up to the maximum 120mg would have been better than adding the quetiapine, imho. Some of us, e.g. me, need a lot of antidepressant to get a worthwhile response.

For some reason I can't fathom, it has become the fashion lately to throw an antipsychotic into the med mix at the first hint an antidepressant isn't working even while at low doses. Imho, it should be the very last thing tried.

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It is the last thing you try to get you out the hole .i was rock bottom and olanzapine saved the day.

I'm on 600mg daily of Pregabalin, 225mg of Venlafaxine + diabetic medications

I was on 20mg of Olanzapine for about 4 years. But when I was in hospital my psychiatrist said that he didn't understand why my GP had even put me on that in the first place as it increases appetite and makes your blood sugar levels rise which was why I was such a badly controlled diabetic!


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Originally Posted by MichelleL

I'm on 600mg daily of Pregabalin, 225mg of Venlafaxine + diabetic medications

I was on 20mg of Olanzapine for about 4 years. But when I was in hospital my psychiatrist said that he didn't understand why my GP had even put me on that in the first place as it increases appetite and makes your blood sugar levels rise which was why I was such a badly controlled diabetic!


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YES you are right its the worst med on the planet for weight issues, i only drop 5mg at night when sleep avoids me , but that dont seem to work now. i am ok with it i am not a diabetic, and it dont give me a food rush, but your gp should have known:shrug: