Took my first imipramine last night. I'm only on 10mg (as well as depression and anxiety I also have M.E. which makes me very sensitive to drugs) and to be taken at night to help with sleep. Well if there's one thing it didn't do it was help me sleep! I was awake all night with tingling and twitching limbs and the most odd feeling like my brain kept twitching or jumping Not a huge amount of fun and I'm rather shattered now - anyone else had similar problems with imipramine/clomipramine and do they go away?