After 4 months of being on pregabalin I don't feel it's having the same effect it once did.

When I last saw my GP he told me they did prescribe duloxetine (some don't due to cost implications). I said I might like to try it in future.

At the moment my anxiety is peaking again, and I have an appt. with my GP on Monday evening.

I'm going to ask to try duloxetine, but I realise I'll have to stop taking mirtazapine too, due to the risk of seratonin syndrome.

I'm hoping I can switch without a tapering period (I've tried several drugs since I first took mirtazapine with only a 48 hour "wash-out" period).

I've booked a few days off work in case of unpleasant side effects (this is my usual strategy when switching meds).

My only concern is that not being on mirtazapine may cause insomnia, this is something that really triggers my anxiety and something that would be a deal-breaker for me if it lasted more than a day or two).

Any experiences or advice would be much appreciated.

Mark