I've been on 15mg mirtazapine for 3 weeks and while it did lift me out of depression after 5 days. I have had a few days where depression has been back so the doctor upped my dose to 30mg from last night. Just wondering how long it will take to take effect. If anybody has upped their dose from 15mg to 30mg I'd love to hear. I'm also on 120mg cymbalta and mirt was added to it to boost it.