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  1. #661
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    Jan 2017
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    Re: A timetable for recovery on Fluoxetine / prozac

    Quote Originally Posted by Dhen1503 View Post
    I dont recall any side effects first time. This is my 5th week on 20mg fluoxetine second time around. I have and still am suffering side effects including no appetite at all, nausea, headache, reflux and heart burn, strange thoughts, increased anxiety, trembling, hot flashes and sweating, lack of urination despite drinking pleanty. I am having to force myself to eat.
    Side-effects can be more severe the second time on an AD and you may also need to take a higher dose to achieve the same level of response too.

    The side-effects are fairly typical of SSRIs. Nausea, reflux and heart burn are caused by fluoxetine's affect on the enteric nervous system (ENS), the mini brain which controls the gut. Serotonin isn't only a brain neurotransmitter. It has many roles in the body and the brain is only a minor user, less than 2% of of the body's serotonin is made and used by it. The most serotonergic organ is the ENS+gut which makes about 50 times as much of it. The gut can therefore be more affected initially by SSRIs/SNRIs and some TCAs than the brain. The usual otc remedies are usually effective.

    The side-effects should begin to diminish as the body responds to the increased serotonin activity by down-regulating its synthesis and expression.

    headache, hot flashes and sweating
    Another of serotonin's roles is in mediating blood vessel tone, constriction and dilation, which trigger these side-effects. Any of the common painkillers should ease the headache, but paracetamol, aka acetaminophen, is a better longer term option than the NSAIDs - aspirin, ibuprofen, naproxen, etc - as SSRIs are also mild anticoagulants.

    Two nights ago I took my tablet before bed instead of in the morning but have felt I'll since. However this could also be due to my fear and anxiety over coronavirus.
    It was most likely the anxiety. Fluoxetine has a very long half-life, about 6 days for fluoxetine itself, plus up to 16 days for its main active metabolite which does most of the work, so minor changes in when the med is taken are unlikely to have any affect.
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  2. #662
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    Mar 2020
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    27

    Re: A timetable for recovery on Fluoxetine / prozac

    Quote Originally Posted by Dhen1503 View Post
    Hi Kay
    I'm on nothing but fluoxetine. I'm not really keen on taking a cocktail of tablets when these worked so well last time on the same dose. I thought side effects were improving but heartburn and really bad headaches have returned along with the other side effects. I forgot to mention before insomnia is another side effect I'm struggling with. Two nights ago I took my tablet before bed instead of in the morning but have felt I'll since. However this could also be due to my fear and anxiety over coronavirus.
    All the best
    David
    I am not taking anything else now either except for a phenergan tablet at night to help me sleep. I was prescribed diazapam to help with the anxiety but It didn't really work too well for me so I managed without.
    When I first posted on here somebody replied that the side effects are worse if you have taken it before. Not sure why but that's definitely been my experience.
    It's such a worrying time for everyone at the moment so anyone with anxiety is bound to struggle more.
    In a way Its almost a positive I haven't been able to work because it's like I've been self isolating already! Sounds like it's probably a good idea you haven't been at work either.

    I can't offer much advice apart from just keep going. You got this far.
    I still wake every day thinking I can't do another day and I'm never going to get better but I do make it through another day and last night I managed to watch something on the TV that I've been looking forward to and I havent managed that before.

    Keep well, stay in as much as you can. That may help with the anxiety over your mum's health.
    X

  3. #663
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    Mar 2020
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    27

    Re: A timetable for recovery on Fluoxetine / prozac

    Quote Originally Posted by panic_down_under View Post
    Try and get out if you can even if its only a walk to the corner of your street and back when few people are about. I'll trade you the grumpy dog for the snoring sheep that has recently decided to sleep under the cabin I'm renting.
    Snoring Sheep!? Sounds like you are out in the country somewhere.
    I think I'm more likely to want to swap the kids!
    Thanks for all your help and advice over the posts x

  4. #664

    Re: A timetable for recovery on Fluoxetine / prozac

    This timeline is based on people not increasing during the 12 weeks. I am about to start week 10 and Iím still having really bad days. If I up my dose Iíve bern told itís like starting the 12 week timeline again. Is this anyoneís experience?

  5. #665
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    Jan 2017
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    Re: A timetable for recovery on Fluoxetine / prozac

    Quote Originally Posted by Sazflux View Post
    I am about to start week 10 and I’m still having really bad days.
    Are they becoming less frequent, or about the same?

    If I up my dose I’ve bern told it’s like starting the 12 week timeline again.
    No, you won't go back to square 1, however, it will take some weeks for the extra dose to begin producing a positive response. How many weeks depends on a number of individual factors so can't be predicted, but probably at least 5 weeks.
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    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

  6. #666
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    Mar 2020
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    27

    Re: A timetable for recovery on Fluoxetine / prozac

    This is my 8 week update!!
    In a strange way 8 weeks has flown by but at times its felt like the longest 8 weeks of my life.
    Ive now got the prospect of another possible 12 weeks in Isolation.
    When I imagined starting to feel better I didn't factor in a Pandemic!! Life throws us some crazy stuff sometimes.
    But the positive is I am starting to feel better. I'm not back to myself yet but I will catch myself at certain times of the day laughing at something or singing and I will feel OK.
    The fear of feeling worse still rumbles under the surface but I'm much more able to reason with myself now and believe this is not forever.
    Getting even to the stage I am now has not been a straight path and I think that's why it's so hard for people suffering to chart their progress.
    I'm still waking stupidly early, 3.15 this morning and I'm not able to fall back to sleep but I'm not crying for hours on end. Oh I'm still crying but it's shorter less intense and I'm able to ease into the day quicker. Saturday and yesterday I managed to be up all day and do some stuff in the garden and play with the kids. Even attempting some housework now!
    It's been a slow gradual process. So frustrating and it's going to be hard trying to find a way through anxiety and depression and everything that's going on in the world.
    Im hoping the improvements for me carry on.
    Sending love xx

  7. #667
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    Jan 2017
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    Re: A timetable for recovery on Fluoxetine / prozac

    Quote Originally Posted by KayMK View Post
    When I imagined starting to feel better I didn't factor in a Pandemic!! Life throws us some crazy stuff sometimes.
    Life is definitely boring atm, Kerri.

    But the positive is I am starting to feel better. I'm not back to myself yet but I will catch myself at certain times of the day laughing at something or singing and I will feel OK.
    Laughing and singing are very good signs. Long may it continue.

    Snoring Sheep!? Sounds like you are out in the country somewhere.
    Yes, well off the beaten track living in the middle of an apple and pear orchard with only some four legged lawn mowers for company, plus a bird which comes to give me a verbal lashing once or twice a day. I don't know what I've done to offend it, but it seems to have a real problem with me.
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    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

  8. #668
    Join Date
    May 2012
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    67

    Re: A timetable for recovery on Fluoxetine / prozac

    I've been on 20mg for 3 months now. It has helped a little but my ocd has gone through the roof this past week. My doctor raised the dose to 40 mg and I took the larger dose this morning. I feel terrible - very high and jittery and I have a really bad headache. Is this dose too high or should I carry on and see if it helps?

  9. #669
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    Jan 2017
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    Re: A timetable for recovery on Fluoxetine / prozac

    Quote Originally Posted by losin View Post
    My doctor raised the dose to 40 mg and I took the larger dose this morning. I feel terrible - very high and jittery and I have a really bad headache. Is this dose too high or should I carry on and see if it helps?
    These side-effects are fairly common when first taking an SSRI, or for a while after dose increases. They are caused by an increase in serotonin activity. Despite the claims, serotonin isn't a 'feel good' neurotransmitter, just the opposite as you've discovered. The brain and body will respond to this by down regulating serotonin synthesis and expression after a while and the side-effects should then diminish.

    Serotonin has many roles in the body (the brain is only a minor user) including in the control of blood vessel tone, constriction and dilation, and it is fluoxetine's impact on this function which is causing the headache. Any of the common painkillers should help, however, paracetamol, aka acetaminophen, is the preferred option if a painkiller is needed for more than a day, or two as it isn't a blood thinner because SSRIs, SNRIs and some TCAs are also mild anticoagulants.
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    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

  10. #670
    Join Date
    May 2012
    Posts
    67

    Re: A timetable for recovery on Fluoxetine / prozac

    I was too scared to take the extra dose yesterday and today but I really need something to get a handle on the neverending fear.
    I've tried all the usual recommendations of healthy diet, excercise, meditation etc but I'm not living life, just lurching from one panicky thought to another and I feel like life is passing me by.
    I might try again tomorrow.

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