Re: A timetable for recovery on Fluoxetine / prozac
Originally Posted by
Don777x
1. Why do you think it is that certain medication stops working after awhile but when you switch to something similar like another ssri, it can work wonders?
I don't know. I don't think anyone does. But while all SSRIs primarily inhibit the serotonin reuptake transporters they each affect other receptor subsystems differently which may account for it. This is also probably why one SSRI is often more effective than the others. That said some find none of them will work after one quits.
2. Do you think since citalopram worked for me for many years and being off it for 4 years it's something that could work for me again? Or do you think I just built up that tolerance and the drug ran its course for good?
Hard to say as there is little data on this. What usually happens is that they are switched to one or two SSRIs after a poop-out and if there is no response, or the second SSRI subsequently quits then a SNRI, or less often a TCA is the next option. Imo, TCAs are the better bet. Not a SNRI fan.
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The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.