It only really started to work for me when I went up to 75mg and though I am bit off it today as I am very hormonal and have headache this meds has given me my life back. I wouldn't mind going up just a titch more to level out the times I have PMT, grrrrrr! But I know when I was on Citalopram that took some time to come completely right. I still get the dry mouth but it doesn't bother me.Good luck xxx