Quetiapine 25mg for anxiety. Anyone had any success?

[Tardisbrain]

Hi Terry are you able to work out how long it would take it to reach therapeutic dose? I am on 25 mg at night for anxiety. If not its no problem, you just seem really clued up on this stuff. Thanks

[MyNameIsTerry]

Hi TardisBrain,

It should reach it's steady-state, when it becomes stable at it's dosage, within 2 days.

[Tardisbrain]

Thanks terry, I think I'm having a wee bit improvement...I'm not sure. Have a nice day

[MyNameIsTerry]

Always good to hear!

[Lan69]

It's a short half life drug so 7 hours for the parent compound and 9-12 hours for the active metabolite.

If you used the standard pharmacokinetic calculation as a guide it would be 5x the half life to get to <5% (clinically insignificant) and 7x for 100% elimination.

So,

5 x 7 = 35 hours
7 x 7 = 49 hours

The active metabolite will be weaker but its not far behind in elimination. After those periods, your med would be adjusted to the new dosage in your blood plasma. Once you take your final dose, it will just then eliminate from there until you are completely free of it but the same rules apply to the timescales.

Thank you Terry
I have been on 25mg for just over a week now and I still find I'm sleeping ok. I just have to decide when to take the jump and stop taking it!

[shiznit76]

OP, are you on it every day or is it as and when needed?

[Neutralview]

At what dose exactly is Seroquel sedating?? Is it sedating at lower doses(25-50mg) or at higher doses (200-300mg)??

[dale12345]

I take 200 hs plus 3 50mgs up to 3 a day prn, it does help with anxiety.