Vortioxetine 10 mg

[TRISTAN]

Has any one in here heard of this one ?

Tried a few meds and not getting anywhere so doc has given me these to try at 10mg .

Start Sunday and coming off mirtazapine and duloxatine

Any advice ????

[panic_down_under]

Has any one in here heard of this one ?

It is a fairly new antidepressant which combines the attributes of a SSRI with that of buspirone (Buspar).

Tried a few meds and not getting anywhere so doc has given me these to try at 10mg .

What have you taken, what was the highest dose you took and how long were you at this dose?

and coming off mirtazapine and duloxatine

What is this fascination UK doctors apparently have with mirtazapine?

[Mermaid16]

What is this fascination UK doctors apparently have with mirtazapine? [/QUOTE]


I think it is the same with Australian doctors. They either prescribe it for insomnia or as a booster to an anti depressant. I take it for insomnia and have tried it at all doses for anxiety, but it has had no effect. It increased anxiety at higher doses. PDU how do you know so much about all this stuff

[BikerMatt]

What is this fascination UK doctors apparently have with mirtazapine? [/QUOTE]

I've been wondering that as everybody seems to be getting prescribed it. Probably cheapest to the NHS or the biggest payers of backhanders. I've decided to come off mirtazapine soon, as I don't rate it.

[panic_down_under]

I think it is the same with Australian doctors. They either prescribe it for insomnia or as a booster to an anti depressant.

Trazodone is better for insomnia as it has a much shorter half-life, only 3-5 hours, so less chance of sedation continuing in to the next morning. Plus, unlike mirtazapine it doesn't induce severe carbohydrate cravings, or poop-out at the drop of a hat.

Buspirone (Buspar) is a better serotonergic antidepressant booster than mirtazapine. EASes some SSRI/SNRI side-effects too. It's especially useful for antidepressant induced sexual dysfunction.

It increased anxiety at higher doses.

Yes, it's a crap med for anxiety, and not much better for depression, imho, except maybe short-term for the very severest form.

PDU how do you know so much about all this stuff

Mostly from participating in forums like this one for over 20 years, plus I used to run a website discussing anxiety/depression research. Learnt a lot from some of the best in the field. Plus I have no life, Waa!! Kidding!

[MyNameIsTerry]

Mirt is usually a second line med from what I've seen in some local NHS guidelines. SSRI's are first line. Second gets you into Mirt, Ven, etc. Pregabalin sits at third line which is the specialist level.

Any combining is for psychiatrists, so level three onwards. Anti psychotics and any Benzo use long term is for then too.

Buspirone isn't licenced beyond short term use specifically stating that there is a lack of evidence that it works. So, it's over to psychiatrists if they want to off label it since a GP won't go against what has come from the licensing and is supported by the NHS evidence base.

Traz can be expensive and I recall reading on some local trust docs that it's higher up in the lines. Mirt is likely to be dirt cheap these days. Anything liquid is always very expensive. Remember that our GP's operate their own budgets so some try to save money rather than serve patient need. Mine just chucks out meds like sweeties and doesn't seem to consider the costs.

[TRISTAN]

I have been on duloxatine for about 6 months on full dose and chucked on mirtazipine for 4 months now , first on 15 then 30 for last 4 weeks , feel so shit on it that leaving the house can feel to much , been reducing for 3 days and then doc said stop and start this in tomorrow morning , I'm reducing duloxatine by 30 mg every five days and just feel scared and full of anxiety and depression

Fingers crossed as tried most others inc citalipram

---------- Post added at 09:18 ---------- Previous post was at 09:17 ----------

I had a big tattoo last week and don't think that's helping as body is trying to fix that instead of me ???????

---------- Post added at 09:20 ---------- Previous post was at 09:18 ----------

Also on pragabalin at top dose so I must be really ill x

[panic_down_under]

Also on pragabalin at top dose so I must be really ill x

No, I suspect what is really sick is the system treating you. Seems to have little flexibility and appears to be fixated on third rate drugs such as mirtazapine and pregabalin which may be making things worse.

Are you being treated by a GP, or psychiatrist? If the former and vortioxetine proves not to be the answer then insist on seeing a psychiatrist. I appreciate that is apparently not as easy as it could/should be.

[TRISTAN]

Psychiatrist I'm afraid x

Mirtazapine is the worst and take last one tonight or might just skip it and start new one ?

---------- Post added at 11:41 ---------- Previous post was at 11:36 ----------

Will one last 15 really make a difference ?

[panic_down_under]

Oops, forgot to address this.

I had a big tattoo last week and don't think that's helping as body is trying to fix that instead of me ???????

It definitely wouldn't be helping. In many respects anxiety disorders and depression are immune system disorders. When the immune system is activated by infection, both anxiety and especially depression can worsen significantly.

This is such an issue that when immune system boosting drugs such as interferon and ribavirin are prescribed to treats viral infections and cancers it has become almost routine to first prescribe a serotonergic antidepressant, especially for patients with a mood disorders history.

---------- Post added at 21:53 ---------- Previous post was at 21:49 ----------

Will one last 15 really make a difference ?

Maybe not, but you wait to see what happens and take it should things take a turn for the worst.