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Thread: Duloxetine with quetiapine

  1. #1
    Join Date
    Oct 2014
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    Duloxetine with quetiapine

    Does anyone take this combo?

    I'm on 30mg duloxetine with 50mg quetiapine for sleep

    I feel like a zombie

    I'm only a week in to taking the duloxetine. will this feeling go?

    Thanks x

  2. #2
    Join Date
    Jan 2017
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    3,555

    Re: Duloxetine with quetiapine

    Quote Originally Posted by Kiwi_87 View Post
    I'm on 30mg duloxetine with 50mg quetiapine for sleep

    I feel like a zombie

    I'm only a week in to taking the duloxetine. will this feeling go?
    I think it more likely the quetiapine is the main reason you feel like a zombie, not the duloxetine.

  3. #3
    Join Date
    Oct 2014
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    91

    Re: Duloxetine with quetiapine

    yeah I was worried about that... 😩 I have to take quetiapine nightly just to sleep because of damn neighbours 😩

  4. #4
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    Jan 2017
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    Re: Duloxetine with quetiapine

    Quote Originally Posted by Kiwi_87 View Post
    yeah I was worried about that... 😩 I have to take quetiapine nightly just to sleep because of damn neighbours 😩
    Quetiapine is highly sedating so maybe try taking only 25mg to see whether it's enough to do the trick without anesthetizing your brain.

    The problem is quetiapine has a longish half-life so the sedation can continue well into the next day. This is why I believe the very short half-life immediate-release trazodone (Desyrel) is the better insomnia treatment, but I understand the NHS bureaucrats aren't fans so GPs can't prescribe it for insomnia. Pity

  5. #5
    Join Date
    Oct 2014
    Posts
    91

    Re: Duloxetine with quetiapine

    good shout, I was thinking the same thing actually. I will try it and see if it works!! eventually I want to come off the damn stuff and not have to rely on it! Xx

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