Hi me again , I am getting to be a pest but sorry I think I just worry to much. I have been on Clomipramine/Anafranil now for about 25 years, started on about 150mg and now am on 20mg a day. I visited mt GP last week who gave me Fluoxetine/Prozac and told me to take 20mg each morning and carry on taking my Clomipramine at night. Every where I have read it says not to take tricyclic and SSRI antidepressants together as they don’t mix? My doc knows I am on both types but just said try them. A month before this I seen a shrink who gave me some seroxat and said start taking ons a day and cut the anafranil in half dose for one week then stop taking the anafranil, I read up on this med and didn’t bother taking it and told my GP this and she agreed. But when I asked do I stop taking anafranil when I start the prozac she said no. I started taking the prozac Friday morning (this is day 4) and this morning I felt worst and shaky and anxious than ever I also had the runs and headache. I usually go out daily with my wife shopping in the car but today was so scared but went anyway. Is this side effects, is it because I am mixing tricylic and SSRI antidepressants, Am I worrying to much reading don’t mix the two or is it Last Thursday I went to see my eye surgeon and the news wasn’t so good?. Sorry for being a pest but I feel worst than I have for ages, and would like to know anyone els been on both or have changed from tricyclics to SSRIs.thanks Vernon