I just picked up my pill bottle of 25MG of Seroquel. I am supposed to just take 1/2 of a tablet at night. Is Seroquel supposed to build up in your system? What effect does it have on anxiety? Right now i increased my dosage of Trintellix and i feel like i am loosing my mind. The doctor wants me to add this to see if we can quiet things down. I wake up shaking everyday and just feel tense and anxious all the time. I'm scared of gaining more weight from this med. I have already gained 35 pounds from overeating caused by other meds that made me constantly hungry. Will i be okay from taking seroquel? Can it cause panic attacks. Please help.