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Thread: Upped to 20mg no effect after 3 weeks

  1. #1

    Upped to 20mg no effect after 3 weeks

    Maybe its too early, but other than additional drowsiness during the day I've notice nothing good (or bad) about Lexapro. Still have exaggerated startle response, still drowsy during the day all day, still palps, still hyperventilation, still cold chills/hot flashes.

    I would have expected to see *something* (even tiny) by now.

  2. #2

    Re: Upped to 20mg no effect after 3 weeks

    its always been a quicker one to work for me.

    Were you on any other before this one?

  3. #3

    Re: Upped to 20mg no effect after 3 weeks

    No this is my first SSRI or anything like this.

  4. #4
    Join Date
    Apr 2018
    Posts
    182

    Re: Upped to 20mg no effect after 3 weeks

    It'll be 5 weeks for me on Wednesday at 10 mg (and 1 1/2 months before that on smaller doses), and I'm still not sure if it's doing anything for me. I'll have a really good day, then a bad day, etc.....and this repeats itself, over and over.

    How long were you on a lower dose before moving up to 20 mg? I feel like it's probably time for me to move up a dose soon.

  5. #5
    Join Date
    Jun 2012
    Posts
    390

    Re: Upped to 20mg no effect after 3 weeks

    3 weeks is not enough. Give yourself close to 8 weeks to really feel the difference. In my case it worked well

  6. #6
    Join Date
    Jan 2017
    Posts
    2,374

    Re: Upped to 20mg no effect after 3 weeks

    Quote Originally Posted by hubble View Post
    I would have expected to see *something* (even tiny) by now.
    It typically takes 4-12 weeks for ADs to kick-in from when a therapeutic dose is first taken (10mg+ for escitalopram) with most beginning to see a positive effect at around 5-7 weeks.

    Antidepressants have no direct effect on anxiety, or depression in the way say aspirin has on a headache. They work by stimulating the growth of new brain cells (neurogenesis) to replace cells killed, or prevented from growing by high brain stress hormone levels. The therapeutic response is produced by these new cells and the stronger interconnections they forge, not the meds directly, and they take time to bud, grow and mature. For a more detailed explanations see: Depression and the Birth and Death of Brain Cells (PDF) and How antidepressant drugs act.
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    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

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