Hi, I have suffered with anxiety/depression for near enough all my life (now 42) and for last 15 years or so tried a variety of neds (fluoxitine, citalopram, escitalopram individually, couldn't tolerate the effects of SSRI's, lofepramine, venlafaxine, both individually and now on combo of mirtazipne and pregablin) I don't think any have helped. Done CBT and talking therapies, none have worked. Feel lost as where to turn to now. I think it is based on genetics as my mum's side of family have had issues over the years. What do I do now if no neds seem to be touching my issues? Any help advice much appreciated. I am due to see private psychiatrist that I have also been paying for rather than being on 6 month waiting list on NHS, next week but any help here would be much appreciated