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Thread: Mirtazapine and Sertraline

  1. #1

    Mirtazapine and Sertraline

    I have been on mirtazapine (45mg) for some time. I also take 2x100mg Pregabalin. The Pregabalin dose has just been increased due to a recent drop in my mood. If this doesn't work my GP. is suggesting dropping the mirt dose lower and possibly introducing Sertraline. Has anyone been in a similar situation? If so what was the change like?

  2. #2
    Join Date
    Nov 2009

    Re: Mirtazapine and Sertraline

    Bumping thread up for you Jools, as I personally have no experience of these meds, but as your post has now moved down the page of 'recent posts'...thought I'd move it up again.

  3. #3

    Re: Mirtazapine and Sertraline

    Thanks. I'm sure someone on here will have some experience on this.

  4. #4
    Join Date
    Jan 2017

    Re: Mirtazapine and Sertraline

    Quote Originally Posted by Jools33 View Post
    If this doesn't work my GP. is suggesting dropping the mirt dose lower and possibly introducing Sertraline.
    Sertraline is likely to do more that mirtazapine and pregabalin as neither are first line anti anxiety meds, imho.

    If so what was the change like?
    SSRIs may trigger some initial side-effects so the trick is to start on a low dose - no more than 25mg, 12.5mg may be even better - and ramp it up by the same small amount at 7-10 day intervals until you get to the minimum therapeutic dose. The recommended dose range is 50-200mg with most needing 100-125mg for optimum results.

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