Hi, I have just been prescribed 140mg of Lofepramine, a TCA that is less sedating than others. I am also taking Doxepin but will eventually taper off it due to it weight gain, I also take Lorazepam and Zopiclone which I want to get off but so many antidepressants have just failed. Psychiatrist prescribed the Lofepramine which I have decided to take 70mg of for a week and then go up to 140mg next week. I am currently on day 2 and feel fine, so far. Just wondering what other peoples experiences of it are. I have a mixed anxiety and depression made worse by hormones at certain times of the month.