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Thread: Mirtazapine 45mg daily Issues

  1. #1
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    Mirtazapine 45mg daily Issues

    Am currently on 45mg daily after titration from 15 through 30 mg daily. Quite a bit of gastric upset. Has anyone else had similar issues? If so, did they resolve over time, or did you have to discontinue the medication?
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  2. #2
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    Re: Mirtazapine 45mg daily Issues

    Quote Originally Posted by sollythegolly View Post
    Am currently on 45mg daily after titration from 15 through 30 mg daily. Quite a bit of gastric upset. Has anyone else had similar issues? If so, did they resolve over time, or did you have to discontinue the medication?
    The most common gastric sided-effect is constipation, with stomach ache uncommon and diarrhoea rare so it might not be the mirtazapine. When did you start taking 45mg?

  3. #3
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    Re: Mirtazapine 45mg daily Issues

    Started on 45mg a week ago. It is quite possible that the gastric upset is not related to that event and is just coincidental. I am aware that stomach pain is one of the less common side effects as well. Just wanted to sound out the collective experience of those members who are taking 45mg.

    Thanks for taking the time to reply. Much appreciated.
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  4. #4
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    Re: Mirtazapine 45mg daily Issues

    As an afterthought, it could be that my gastro issues are caused by added anxiety at having the dose ramped up to the maximum recommended. Just a thought.....
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  5. #5
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    Re: Mirtazapine 45mg daily Issues

    Quote Originally Posted by sollythegolly View Post
    As an afterthought, it could be that my gastro issues are caused by added anxiety at having the dose ramped up to the maximum recommended. Just a thought.....
    It is certainly a possibility. The gut has its own mini brain, the enteric nervous system (ENS) which is linked to the brain between our ears via the vagus nerves. While the gut seems to be the dominant partner with most of the 'data' being sent from it, rather than to it from the brain, an anxious brain can trigger the ENS into producing the gastric symptoms often associated with anxiety. It might also be that the ENS can trigger anxiety and depression which opens the possibility diet, or the mix of gut flora influences these disorders.

  6. #6
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    Re: Mirtazapine 45mg daily Issues

    Thatís a very good explanation. Thanks for that.

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