Page 1 of 2 12 LastLast
Results 1 to 10 of 12

Thread: Increase in sertraline

  1. #1
    Join Date
    Mar 2017
    Posts
    470

    Increase in sertraline

    So Iíve upped my dosage by 50mg each week and Iíve been on for 4 weeks Iím staying in 150mg but my anxiety is through the roof, and my tummy is in knots who else had the increase in anxiety with sertraline


    Sent from my iPhone using Tapatalk

  2. #2
    Join Date
    Jan 2017
    Posts
    1,454

    Re: Increase in sertraline

    Quote Originally Posted by Noworryjonny View Post
    So Iíve upped my dosage by 50mg each week and Iíve been on for 4 weeks Iím staying in 150mg but my anxiety is through the roof, and my tummy is in knots who else had the increase in anxiety with sertraline
    Probably nearly everyone with an anxiety disorder who has taken a serotonergic antidepressant. It is a very common initial side-effect caused by the immediate increase in serotonin activity. Despite the popular myth, serotonin is not a 'feel good' neurotransmitter. The tummy and gut can be especially affected because the gut is by far the most serotonergic organ of the body making and using about 60 times more serotonin than the brain.

    The heightened anxiety and other side-effects usually begin to diminish once plasma levels of the med stabilize to a steady-state and the brain and other affected organs respond by down-regulating serotonin synthesis and expression, though they may reoccur for a short period after dose increases. Talk to the prescribing doctor if the anxiety become intolerable as there are ways of easing it.

  3. #3
    Join Date
    Mar 2017
    Posts
    470

    Re: Increase in sertraline

    Thank you so what Iím feeling in my stomach is to be expected considering the dosage increase and the short amount of time Iíve been on it


    Sent from my iPhone using Tapatalk

  4. #4
    Join Date
    Jan 2017
    Posts
    1,454

    Re: Increase in sertraline

    Quote Originally Posted by Noworryjonny View Post
    so what Iím feeling in my stomach is to be expected considering the dosage increase and the short amount of time Iíve been on it
    Unfortunately, yes. The side-effects usually begin to diminish after a few weeks, though they can linger for some and may return for a while after dose increases, but stomach and gut issues are common and not anything to worry about. The usual remedies for upset stomach, etc, may help.

  5. #5
    Join Date
    Feb 2011
    Posts
    767

    Re: Increase in sertraline

    I've just increased my Sertraline dose from 50mg to 100mg and am experiencing similar problems. I wasn't coping on 50mg but increasing the dose has led to stomach issues and increased anxiety as a result. I know this should only be temporary, but it is so hard. Has anyone on the forum got positive results of this kind of increase? If so, how long did it take for the meds to kick in? Do you feel much better on the higher dose? Taking increasingly higher doses really scares me, I never wanted to be dependant on medication just to make me feel normal. It just makes me feel less in control of my own body. I then get scared it will stop working and I'll have to go for a higher dose still. Where will it end?

  6. #6
    Join Date
    Jan 2017
    Posts
    1,454

    Re: Increase in sertraline

    Quote Originally Posted by Tyke View Post
    I wasn't coping on 50mg but increasing the dose has led to stomach issues and increased anxiety as a result. I know this should only be temporary, but it is so hard. Has anyone on the forum got positive results of this kind of increase?
    50mg is the usual sertraline starting dose for depression (<=25 mg for anxiety) and the minimum therapeutic dose. Most need to take 100-150mg to get a good response so your experience is pretty much the norm.

    Taking increasingly higher doses really scares me, I never wanted to be dependant on medication just to make me feel normal. It just makes me feel less in control of my own body.
    Would you feel this way if you had say epilepsy, or an autoimmune disease like rheumatoid arthritis? Anxiety disorders [1] share much the same benzodiazepine binding site deficiencies as epilepsy [2], and are, with depression, the symptoms of atrophy of parts of the hippocampal regions of the brain caused by high brain stress hormone levels, mostly of cortisol, which kills brain cells and inhibits the growth of new ones, i.e. essentially an auto immune response. High cortisol levels are also associated with immune system disorders such as multiple sclerosis. Antidepressants (ADs) and therapy work by turbo charging the growth of new hippocampal cells (as can to lesser extents exercise and Omega-3/fish oil supplements). The therapeutic response is produced by the new cells and the interconnections they forge, not the meds directly.

    I then get scared it will stop working and I'll have to go for a higher dose still. Where will it end?
    It is possible that you may need a higher dose, it all depends on how well sertraline meshes with your DNA and how quickly you metabolize the med, however, most people do not need to continually increase AD doses over time. I've been on the same AD dose for about 25 years, even though as a rapid metaboliser I have always needed to take near the maximum dose of the ADs I've been on and in some cases well above the recommended maximum.



    References:

    [1]
    Altered cerebral benzodiazepine receptor binding in post-traumatic stress disorder.
    Transl Psychiatry. 2018 Oct 4;8(1):206 (Abstract | Full text)

    Hasler G, Nugent AC, Carlson PJ, et al. (2008)
    Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomography.
    Arch Gen Psychiatry. Oct;65(10):1166-75 (Abstract)

    Geuze E, van Berckel BN, Lammertsma AA, et al. (2007)
    Reduced GABAA benzodiazepine receptor binding in veterans with post-traumatic stress disorder.
    Mol Psychiatry. 2008 Jan;13(1):74-83 (Abstract)

    Cameron OG, Huang GC, Nichols T, et al. (2007)
    Reduced gamma-aminobutyric acid(A)-benzodiazepine binding sites in insular cortex of individuals with panic disorder.
    Arch Gen Psychiatry. Jul;64(7):793-800. (Abstract)

    Bremner JD, Innis RB, Southwick SM, et al. (2000)
    "Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder."
    Am J Psychiatry Jul; vol 157(7):1120-6 (Abstract)

    Bremner JD, Innis RB, White T, et al (2000)
    "SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder."
    Biol Psychiatry Jan 15; vol 47(2):96-106 (Abstract)

    Malizia AL. (1999)
    "What do brain imaging studies tell us about anxiety disorders? "
    J Psychopharmacol Dec; vol 13(4):372-8 (Abstract)

    Morimoto K. 1999
    Benzodiazepine receptor imaging in the brain: recent developments and clinical validity
    Kaku Igaku. May;36(4):307-13. (Abstract)

    Malizia AL, Cunningham VJ, Bell CJ, et al. (1998)
    "Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study."
    Arch Gen Psychiatry Aug; vol 55(8):715-20 (Abstract)

    Tokunaga M, Ida I, Higuchi T, Mikuni M. (1997)
    "Alterations of benzodiazepine receptor binding potential in anxiety and somatoform disorders measured by 123I-iomazenil SPECT."
    Radiat Med May-Jun; vol 15(3):163-9 (Abstract)

    Uchiyama M, Sue H, Fukumitsu N, et al. (1997)
    "Assessment of cerebral benzodiazepine receptor distribution in anxiety disorders by 123I-iomazenil-SPECT: comparison to cerebral perfusion scintigraphy by 123I-IMP."
    Nippon Igaku Hoshasen Gakkai Zasshi Jan; vol 57(1):41-6 (Abstract)

    [2]

    Vivash L, Tostevin A, Liu DS, et al. (2011)
    "Changes in hippocampal GABAA/cBZR density during limbic epileptogenesis: relationship to cell loss and mossy fibre sprouting."
    Neurobiol Dis. Feb;41(2):227-36. (Abstract)

    Morimoto K. (1999)
    "Benzodiazepine receptor imaging in the brain: recent developments and clinical validity."
    Kaku Igaku May; vol 36(4):307-13 (Abstract)

    Savic I, Pauli S, Thorell JO, Blomqvist G. (1994)
    "In vivo demonstration of altered benzodiazepine receptor density in patients with generalised epilepsy."
    J Neurol Neurosurg Psychiatry. Jul;57(7):797-804. [Abstract]

  7. #7
    Join Date
    Jul 2005
    Location
    , , Australia.
    Posts
    1,662

    Re: Increase in sertraline

    50mg worked just fine for me for 3 years but I just didn't like Sert in general so I swapped to 10mg Lexapro and all is good
    __________________
    Don't believe everything you think.

    Don't be afraid that your life will end, be afraid that it will never begin.

  8. #8
    Join Date
    Feb 2011
    Posts
    767

    Re: Increase in sertraline

    Gee thanks for that guys. And thanks for all the useful information and references Panic_Down_Under.

    I do love the international feel to this forum, we're all in the same boat with these issues, wherever we are. I'll raise a glass to all of you down under regardless of who wins the Ashes!!!

    I'm having a better day today. The stomach problems and increased anxiety are still there, but I feel I can accept it more easily now.

    You're quite right with your comparisons with medication and other health problems Panic_Down_Under. The brain is after all, just another part of the body that needs help in functioning correctly sometimes.

    Best wishes to you all.
    Tyke

  9. #9
    Join Date
    Jan 2017
    Posts
    1,454

    Re: Increase in sertraline

    Quote Originally Posted by Tyke View Post
    I'll raise a glass to all of you down under regardless of who wins the Ashes!!!
    I fear we lost it when we didn't take full advantage of the first innings collapse in the last test. I blame our selectors. I've made myself available for selection to open both the batting and bowling every year for the last 55, but, inexplicably, never received the call. Clearly, there has been skulduggery afoot all these years, despotism and rampant corruption leavened only by gross incompetence!

    I'm having a better day today. The stomach problems and increased anxiety are still there, but I feel I can accept it more easily now.
    Sounds promising. You might not be out of the woods yet, but it seems you're headed in the right direction at last.

    The brain is after all, just another part of the body that needs help in functioning correctly sometimes.
    Some more than others, as my shrink likes to tell me while raising one eyebrow. But then his shrink probably has the same dark thoughts about his!

  10. #10
    Join Date
    Mar 2017
    Posts
    470

    Re: Increase in sertraline

    Iíve been on 150mg for 7 weeks and I had a few good days but the last four days the stomach issues have come back in full force the anxious tummy and diarrhoea have been horrible doctor said itís normal when I saw him today as Iím on a High dose


    Sent from my iPhone using Tapatalk

Page 1 of 2 12 LastLast

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Similar Threads

  1. Sertraline increase from 25 to 50mgs
    By ckyrule in forum Sertraline / Zoloft / Lustral
    Replies: 2
    Last Post: 08-09-18, 23:19
  2. Increase to 150 mg Sertraline Week 6
    By MadWomanintheAttik in forum Sertraline / Zoloft / Lustral
    Replies: 2
    Last Post: 14-04-18, 01:43
  3. Sertraline increase
    By milliemoo in forum Sertraline / Zoloft / Lustral
    Replies: 1
    Last Post: 05-09-17, 02:10
  4. Increase Sertraline Dosage
    By amir-b in forum Sertraline / Zoloft / Lustral
    Replies: 0
    Last Post: 06-10-15, 14:19
  5. Should I increase my sertraline for HA?!
    By Help1989 in forum Health Anxiety
    Replies: 4
    Last Post: 28-06-15, 06:25

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •