Thank you both for your replies. Really helpful to know. I've been worrying mildly about serotonin levels with this current regime but hopefully it's ok. The thought of coming off ven terrifies me and I have heard its not nice. I'm not really keen to increase it further. Today has been ok, I've just felt very tired which I guess is to be expected. I've emailed the psych to say basically I don't want to stop mirt, but haven't heard back yet. I might drop it to 7.5mg but I'm not willing to stop it yet. Pulisa - would mirtazapine be an option for your son? I have found it amazing for sleep. I'll definitely keep you posted. Not too sure when I'll increase the quetiapine again, I might leave it a bit longer. Thank you again, and PDU, I will ask him about those drugs if this regime doesn't work out. I asked about trazodone a while ago after you mentioned it but at the time he preferred for me to have mirt, don't know why.