Page 1 of 3 123 LastLast
Results 1 to 10 of 22

Thread: Anyone take anything alongside Mirtazapine? Help required please.

  1. #1
    Join Date
    Jan 2013
    Posts
    1,388

    Anyone take anything alongside Mirtazapine? Help required please.

    I have an appt coming up in December with the MH team psychiatrist.

    At one time I was taking Seroxat, Mirtazapine and Propranolol. I decided to rid myself of all meds in 2015 so came off Seroxat which took nearly a year then the Propranolol in 2017. I've stayed on Mirtazapine but I'm really struggling and have done for a long time. I tried Venlafaxine a couple of years ago and the side effects were severe so stopped and then got offered Qutiapine but decided against it.

    Any advice would be appreciated on what people take or have taken with Mirtazapine? Or should I try Qutiapine (still with Mirtazapine)? Just won't to arm myself with info before my appt.

    Ta

  2. #2
    Join Date
    Jan 2017
    Posts
    1,759

    Re: Anyone take anything alongside Mirtazapine? Help required please.

    Quote Originally Posted by BikerMatt View Post
    Any advice would be appreciated on what people take or have taken with Mirtazapine? Or should I try Qutiapine (still with Mirtazapine)? Just won't to arm myself with info before my appt.
    Firstly, is this for an anxiety disorder, depression, both?

    Quetiapine and mirtazapine pretty much hit the same receptors to the same extent with the main difference being quetiapine binds to one of the dopamine receptors a little more strongly. So there's not much point taking both. I'm not a fan of either as, imho, the often modest response is outweighed by the side-effects risk, particularly the common weight gain.

    How much paroxetine (Seroxat) were you taking and was it fully effective? I'm guessing not if it was being supplemented by mirtazapine and propranolol.

  3. #3
    Join Date
    Jan 2013
    Posts
    1,388

    Re: Anyone take anything alongside Mirtazapine? Help required please.

    Hi PDU,

    It's for anxiety, depression, daily panic attacks and I've been having suicidal thoughts.

    I was taking Seroxat 20mg when the Mirtazapine was added in 2014 and Propranolol 80mg xr in 2015.

    I didn't think the Seroxat was doing anything and wanted to take the chance to come off it as it's a monster to come off.

    Not worried about weight gain but when I tried Venlaxafine it had me laying in a pool of sweat, wooshing in my ears, nausea from another planet and gave me a horrific headache.
    Last edited by BikerMatt; 13-10-19 at 13:18.

  4. #4
    Join Date
    Jan 2017
    Posts
    1,759

    Re: Anyone take anything alongside Mirtazapine? Help required please.

    Quote Originally Posted by BikerMatt View Post
    Hi PDU,

    It's for anxiety, depression, daily panic attacks and I've been having suicidal thoughts.

    I was taking Seroxat 20mg when the Mirtazapine was added in 2014 and Propranolol 80mg xr in 2015.
    So paroxetine wasn't working well enough and instead of increasing the dose above the minimum your GP decided to just keep adding more meds in the hope something would stick?

    Did paroxetine work for a while and then poop-out, or not really work at all?

    I didn't think the Seroxat was doing anything and wanted to take the chance to come off it as it's a monster to come off
    It is the second most difficult AD to quit because of its short half-life and lack of an extending active metabolite.

    Not worried about weight gain but when I tried Venlaxafine it had me laying in a pool of sweat, wooshing in my ears, nausea from another planet and gave me a horrific headache.
    Most believe that venlafaxine is the hardest AD to quit, again because of its half-life which is even shorter than paroxetine's, although it does have an active metabolite. Given your experience quitting paroxetine I suggest you give it, and all the other SNRIs, a very wide berth. Despite the claim, venlafaxine is just another SSRI, not a SNRI, having only a weak affect on noradrenaline/norepinephrine reuptake even at the maximum dose so doesn't have much, if any, advantage over other SSRIs.

  5. #5
    Join Date
    Jan 2013
    Posts
    1,388

    Re: Anyone take anything alongside Mirtazapine? Help required please.

    Hi PDU, I had taken Seroxat for around 10 years and didn't really feel it was working.

    I have now paid to see a Neuro-otologist as I had been referred to London through the NHS, but my appt isn't until Jan after waiting 13 months.

    The Neuro-otologist suggested Venlafaxine (which I can't tolerate), Gabapentin or Pizotifen.

    I started Gabapentin on Thurs. I wanted to try the gabapentin as it also has good reviews for anxety/panic (off label) as well as trying to sort out my 24/7 dizziness.
    Last edited by BikerMatt; 20-10-19 at 22:44.

  6. #6
    Join Date
    Feb 2016
    Posts
    1,649

    Re: Anyone take anything alongside Mirtazapine? Help required please.

    Hi Matt , good to see you are still in the land of the living, that is some list of meds and f**k you’ve been trying different ones for some time , I don’t do meds myself due to them putting me in this position in the first place but I know they work for some , my partner tried Mirtazepene and said it was awful with no benefits, a couple of people I’ve spoken to on here seemed worse on it and once they came off it they got better and left the site , it’s all a bit suck it and see with meds docs don’t seem to have a clue , once they suggested putting me on anti psychotics I thought f**k that I’ll treat myself .
    So I don’t have the answer no one does , I take CBD oil every day and the odd diazepam to take the edge off on a real bad day , a couple of weeks ago I tried home made shock therapy, I stood behind a Typhoon jet taking off at RAF Coningsby which nearly gave me a heart attack and I also stood in front of the sea wall in a storm , my theory was it would scare me so much everything else would be a doddle , it didn’t really work but I have noticed a difference since taking the cbd .
    I saw Doc on tv last week saying 50 % of people taking anti depressants got better then he added 25% given placebos got better , it’s a very complicated bowl of noodles we carry round on our shoulders .
    Take care mate and good to read you lad is doing better as well .

  7. #7
    Join Date
    Jan 2017
    Posts
    1,759

    Re: Anyone take anything alongside Mirtazapine? Help required please.

    Quote Originally Posted by BikerMatt View Post
    Hi PDU, I had taken Seroxat for around 10 years and didn't really feel it was working.
    So you feel it never worked during the 10 years, or that it stopped working recently?

    The Neuro-urologist suggested Venlafaxine (which I can't tolerate), Gabapentin or Pizotifen.
    Why a neurologist and not a psychiatrist?

    Gabapentin works well for some though these days the similar pregabalin (Lyrica) is prescribed more frequently.

    Pizotifen is a migraine med which is little prescribed these days because of its side-effects. Like most antihistamines it can ease anxiety by sedation and antagonizing (blocking) some of the same serotonin receptors as mirtazapine, which might be enough for some, but it's not a first line anxiety med. I don't recall anyone having been on it.

  8. #8
    Join Date
    Jan 2013
    Posts
    1,388

    Re: Anyone take anything alongside Mirtazapine? Help required please.

    Quote Originally Posted by panic_down_under View Post
    So you feel it never worked during the 10 years, or that it stopped working recently?



    Why a neurologist and not a psychiatrist?

    Gabapentin works well for some though these days the similar pregabalin (Lyrica) is prescribed more frequently.

    Pizotifen is a migraine med which is little prescribed these days because of its side-effects. Like most antihistamines it can ease anxiety by sedation and antagonizing (blocking) some of the same serotonin receptors as mirtazapine, which might be enough for some, but it's not a first line anxiety med. I don't recall anyone having been on it.
    PDU, I have been suffering with 24/7 dizziness, off-balance, bobbing/swaying and walking on a mattress feelings since July 2017. A neuro-otologist specialises in disorders that cause dizziness and he thinks it might be migraine variant balance disorder and some treatments for this medication wise cross over with anti anxiety meds.

    This has all made me feel the worse I have ever done MH wise as it's taken so long to get as far as I have with the NHS and 24/7 dizziness isn't fun and has landed me begging for help from the MH team, but I'm having to wait until December (4 1/2 months from referral) for the Psychiatrist appt.

    Seroxat never made me feel how I think it should've as I made a massive effort with lifestyle changes/removing stressors from my life, CBT, Stress management courses etc.

    I just know that the Psych is just going to want to slap me on meds but some of the combos and mg I see people taking here is scary. I'm happy to add something to my Mirt.

  9. #9
    Join Date
    Jan 2013
    Posts
    1,388

    Re: Anyone take anything alongside Mirtazapine? Help required please.

    Ps They won't prescribe Preg here often as Gaba is so much cheaper. I'm keeping Gaba to a low dose and seeing the Neuro-otologist again mid November. I'm going to ask him about Preg and if he says yes my GP will more than likely have to prescribe it.

  10. #10
    Join Date
    Jan 2017
    Posts
    1,759

    Re: Anyone take anything alongside Mirtazapine? Help required please.

    Quote Originally Posted by BikerMatt View Post
    Ps They won't prescribe Preg here often as Gaba is so much cheaper. I'm keeping Gaba to a low dose and seeing the Neuro-otologist again mid November. I'm going to ask him about Preg and if he says yes my GP will more than likely have to prescribe it.
    The problem with gabapentin is that it has low bioavailability and this becomes progressively less so as the dose increases, but the side-effects impact tends to be more linear. At the usual minimum 900mg daily dose only about 60% is absorbed for an effective dose of 540mg, at 2,400mg bioavailability is only 34%, so taking 2.7 times as much just increases the amount of drug in the system by only 50%. Taking it with food slightly increases its bio availability, but avoid taking it within 2-3 hours of taking an antacid.

    Pregabalin is absorbed faster and has much higher (~90%) linear bioavailability so less med needs to be taken and the side-effects tend to be less severe at equivalent effective doses, especially at the upper end of their ranges.

Page 1 of 3 123 LastLast

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Similar Threads

  1. Anyone taken 10mg Ami alongside 20mg fluoxetine?
    By Issy2017 in forum Amitriptyline
    Replies: 0
    Last Post: 15-07-18, 15:17
  2. Taking another med for anxiety alongside Escitalopram
    By Buckinghamshirelady in forum Escitalopram / Lexapro / Cipralex
    Replies: 1
    Last Post: 25-07-15, 10:11
  3. Help Required!!!
    By paulb3676 in forum Mirtazapine /Zispin
    Replies: 0
    Last Post: 23-08-13, 15:49
  4. Help required please.
    By hyperlogic in forum General Anxiety / Generalised anxiety disorder (GAD)
    Replies: 3
    Last Post: 24-10-09, 16:24

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •