I would say try not to feel sorry for yourself no matter how bad you feel. It just makes things worse and reinforces the feeling that things will never get better.

Give the duloxetine a chance? I know you've been on tonnes of meds before with no real success but you've got a new doctor with a new approach now so you've got to have faith until you know for sure that things aren't improving?

My son is switching to duloxetine too-he's got quite complex issues so it's a gamble. He has been to the darkest places in the last few weeks-you will know all about this though. You have to try something to get you through the days when everything seems hopeless and pointless, Paul and you are and you do.