The lack of anxiety and depression may be partly due to the longish mirtazapine half-life and also the hydroxyzine. It tickles most of the same receptors to about the same degree. It is also a fairly potent anxiolytic. Not quite in the same league as BZDs, but pretty good.
The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.
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