Page 3 of 3 FirstFirst 123
Results 21 to 25 of 25
  1. #21
    Join Date
    Mar 2011
    Posts
    460

    Re: Imipramine, have I made the right choice?

    Many thanks for that reply and information which I have just skimmed through now but will read in detail tomorrow.
    And sorry PDU, I realized afterwards that I had referred to Imipramine instead of Trimipramine - can I borrow your D'oh!

  2. #22
    Join Date
    Nov 2012
    Posts
    159

    Re: Imipramine, have I made the right choice?

    Quick update. My dosage was increased to 50mg yesterday. So far no more issues and I have been sleeping quite well. I have noticed I seem to experience more highs and lows emotionally than I have ever on ssris.

  3. #23
    Join Date
    Jan 2017
    Posts
    2,114

    Re: Imipramine, have I made the right choice?

    Quote Originally Posted by Dazzlar13 View Post
    Quick update. My dosage was increased to 50mg yesterday. So far no more issues and I have been sleeping quite well.
    The TCAs tend to produce milder initial side-effects than the SSRIs/SNRIs, however, they tend to have more ongoing ones, mostly dry-mouth and constipation which can be managed. Insomnia is also much less likely with TCAs than SSRIs/SNRIs because TCAs are mild to powerful antihistamines.

    I have noticed I seem to experience more highs and lows emotionally than I have ever on ssris.
    It is early days and you're on a low dose so I wouldn't read too much into this. Some of it could also be a rebound from sertraline if it had dampened emotions.
    __________________
    .

    - - What to know about: Telepsychiatry | Teletherapy - -





    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

  4. #24
    Join Date
    Nov 2012
    Posts
    159

    Re: Imipramine, have I made the right choice?

    I have a six month baby at home but I have just noticed I feel much happier generally than I have in a long time. But if I see something sad on TV for instance it just seems to have more of an effect on me. I do put it down to the emotional blunting from sertraline and duloxetine earlier.

    I have noticed I have more vivid dreams also.

    I see the recommend dose is 125mg and my doctor is only increasing it 25 mg every 2 weeks and I'm a big guy as well coming in at 260lbs. It's going to take a while before I get the full effect.

  5. #25
    Join Date
    Jan 2017
    Posts
    2,114

    Re: Imipramine, have I made the right choice?

    Quote Originally Posted by Dazzlar13 View Post
    I do put it down to the emotional blunting from sertraline and duloxetine earlier.
    Possibly. Some ADs may have that affect on some people. Switching to another AD will usually resolve the issue, however, some prefer the blunting.

    I have noticed I have more vivid dreams also.
    I suspect the dreams don't actually change. That they are just as vivid most of the time, but ADs may lighten REM sleep enough for them to intrude into conscious awareness. I used to have some beauties on imipramine. The full DeMille extravagances in widescreen Technicolor with surround sound...well if DeMille was on crack, some were really weird! Haven't taken it for over 25 years, but I still miss them.

    I see the recommend dose is 125mg and my doctor is only increasing it 25 mg every 2 weeks and I'm a big guy as well coming in at 260lbs. It's going to take a while before I get the full effect.
    Patience is a virtue and that applies double where ADs are concerned. Better to go slow to minimize the initial side-effects than to rush it. The usual effective dose range is 100-200mg, but a few may need more. I was on 350mg for a while.

    Body weight doesn't matter much. Antidepressants have no direct effect on anxiety, or depression in the way say aspirin has on a headache. They work by stimulating the growth of new brain cells (neurogenesis) to replace cells killed, or prevented from growing by high brain stress hormone levels. The therapeutic response is produced by these new cells and the stronger interconnections they forge, not the meds directly, and they take time to bud, grow and mature. For a more detailed explanations see: Depression and the Birth and Death of Brain Cells (PDF) and How antidepressant drugs act.
    __________________
    .

    - - What to know about: Telepsychiatry | Teletherapy - -





    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

Page 3 of 3 FirstFirst 123

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Similar Threads

  1. I made it out and then decided to tapper out... Wrong choice!
    By Aranden in forum General Anxiety / Generalised anxiety disorder (GAD)
    Replies: 4
    Last Post: 26-10-16, 10:29
  2. Imipramine
    By Lee2475 in forum Medication
    Replies: 0
    Last Post: 13-03-15, 17:10
  3. Imipramine - anyone tried it?
    By rocklover in forum Medication
    Replies: 22
    Last Post: 24-02-13, 19:48
  4. Imipramine/Clomipramine
    By dan1234 in forum Anafranil / Clomipramine
    Replies: 8
    Last Post: 09-07-12, 17:56
  5. imipramine
    By Attsila in forum Medication
    Replies: 1
    Last Post: 03-07-06, 18:26

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •