Re: Coming off quetiapine

Originally Posted by
lebonvin
I gotta come off Q coz can't get no more. Been on 50mg for sleep 5 years n it works real good.
So I taking 25mg one nite, 50mg the next. Sleep 6 hours on 25mg and sometimes 10 hours on 50mg. Something tells me this ain't way to go.
No, it isn't the right way to do it as quetiapine has a short 6-7 hour half-life so taking it that way can set up a yo-yo effect which can become very disturbing.
Should I try break a pill and hang on 37mg a while? Or just go for it and only take 25mg?
You will probably have relatively few issues dropping back to 25mg/day for a week or two and then quitting. Note: XR tablets should not be cut, or crushed.
I asked similar question before and Ian said I could switch to hydroxozone a antihistamine but can't get anything to replace Q with.
Diphenhydramine (Benadryl) may help with rebound insomnia, but not with withdrawal effects triggered by the loss of activity on other receptors. Check that the Benadryl you has diphenhydramine as the active ingredient as some formulations contain non sedating antihistamines.
If I stop completely any idea how long insomnia will last? I got experiencing of similar when I come CT offa Xanax. 2 weeks without any sleep.
Unfortunately, this is a 'how long is a piece of string' question which can only be answered with, "it depends." It may be anywhere from little if any loss of sleep to several weeks of watching early AM reruns of I Love Lucy.
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The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.