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Thread: Low dose nortriptyline

  1. #11
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    Feb 2016
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    Re: Low dose nortriptyline

    Quote Originally Posted by panic_down_under View Post
    Nortriptyline is only mildly sedating. Its parent amitriptyline is much more potent in that regard. Unfortunately, this is the biggest drawback of most antidepressants, they often make anxiety worse in the beginning. It usually diminishes after a week, or two, but may return for a while following dose increases.
    If you're looking for a sedating effect then Ami is the one to try and I'd try a low dose if the Nortripyline doesn't suit you. I don't know what dose you're taking but I didn't get any anxiety symptoms on either Doxepin (unavailable now) or Ami. The only noticeable symptoms I had was dry mouth and that wears off after a while.

    TCA's suit some people's systems whereas the SSRI's and SNRI's just don't due to bad anxiety. It's good they're still available.
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  2. #12
    Join Date
    Dec 2016
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    112

    Re: Low dose nortriptyline

    Just an update on this. Been taking it for 6 or 7 weeks now. The nortriptyline is going well. All the side effects disappeared after the first few weeks. However right now I feel like the chronic pain and IBS treatment benefits are also starting to wear off. I’m thinking I might ask for a higher dose. I’m only on 10mg. I have my follow up appointment next week to assess things with my doctor.

  3. #13
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    Jan 2017
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    Re: Low dose nortriptyline

    Quote Originally Posted by Librella View Post
    However right now I feel like the chronic pain and IBS treatment benefits are also starting to wear off. I’m thinking I might ask for a higher dose. I’m only on 10mg.
    The usual nortriptyline dose range for pain and IBS is 10-50mg with most taking 25-50mg.
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  4. #14
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    Dec 2016
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    Re: Low dose nortriptyline

    I increased to 25mg. It's been a week and I don't feel any different, still like the efficacy has worn off which is disappointing. Will it take another few weeks for the benefits of the increased dose to be seen?

  5. #15
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    Re: Low dose nortriptyline

    Quote Originally Posted by Librella View Post
    I increased to 25mg. It's been a week and I don't feel any different, still like the efficacy has worn off which is disappointing. Will it take another few weeks for the benefits of the increased dose to be seen?
    It (and other ADs) typically takes 4-6 weeks to reach peak effectiveness for general pain and migraines so don't give up on it yet.
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  6. #16
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    Dec 2016
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    112

    Re: Low dose nortriptyline

    I’m having some unpleasant side effects now. Dry mouth and constipation. I’m taking this for ibs so it’s just made me swing the other way! I messaged my doctor, but does anyone know if these side effects will fade after a few weeks or will it be something I deal with long term? I noticed the change when I went from taking 2 of the 10mg pills together to just one 25mg pill 2 weeks ago but I wouldn’t think there was so much difference in 5mg.

  7. #17
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    Re: Low dose nortriptyline

    Quote Originally Posted by Librella View Post
    Iím having some unpleasant side effects now. Dry mouth and constipation. Iím taking this for ibs so itís just made me swing the other way! I messaged my doctor, but does anyone know if these side effects will fade after a few weeks or will it be something I deal with long term? I noticed the change when I went from taking 2 of the 10mg pills together to just one 25mg pill 2 weeks ago but I wouldnít think there was so much difference in 5mg.
    It seems the extra 5mg has taken the dose above the tripping point. Dry mouth and constipation are frequent ongoing side-effects of some TCAs due to their effect on acetylcholine receptors. I can't say whether they will be transient, or permanent. At typical antidepressive doses they would probably be permanent, but at low doses they may diminish after a few weeks. If they are still an issue after 4-6 weeks they will likely continue to some extent as long as you're taking nortriptyline. Sipping water and stool softeners should help.
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