So Iíve been on the increased dose of mirtazapine for 5 weeks today, also on 300mg venlafaxine and 300mg quetiapine. At the two week mark I started to feel normal again, lasted 4 or 5 days then back to feeling hopeless and terrified. A couple of good days in week 3 then doom and gloom again followed by a few good days at the start of week 4. Iím back in doomsville again the last few days and feeling very tearful and terrified. I should know the answer by now but just canít reassure myself is this rollercoaster normal. I was feeling so hopeful last week that things were on the up but now Iím terrified the increase wonít work and I canít bear the thought of another med change