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Thread: Sertraline: from 100mg to 50mg

  1. #1
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    Sertraline: from 100mg to 50mg

    Anyone reduced their sertraline dose? How did you go about it? I am thinking of coming down from 100 mg to 50 mg to see if it helps with some side effects. Should I go straight down to 50mg or take 75 mg for some time first? Thank you

  2. #2
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    Re: Sertraline: from 100mg to 50mg

    Quote Originally Posted by USER12 View Post
    Anyone reduced their sertraline dose? How did you go about it? I am thinking of coming down from 100 mg to 50 mg to see if it helps with some side effects.
    What side-effects are you concerned about?

    Should I go straight down to 50mg or take 75 mg for some time first?
    I'd go down via at least 7-10 days at 75mg, but maybe stay at 75mg for a few weeks to see if this eases the side-effects enough.
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  3. #3
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    Re: Sertraline: from 100mg to 50mg

    It’s bruxism, been experiencing that for a few months now. Thank you for the advice.

  4. #4
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    Re: Sertraline: from 100mg to 50mg

    Quote Originally Posted by USER12 View Post
    It’s bruxism, been experiencing that for a few months now.
    Have you mentioned it to your GP? The addition of 10-40mg of buspirone (Buspar) will often resolve it. Buspirone is a GAD specific med which works well for some, but not for most but when taken with serotonergic ADs it may increase their effectiveness and diminish their side-effects.

    Sertraline, fluoxetine, paroxetine and venlafaxine are the ADs most likely to trigger bruxism although it may occur with any of the SSRIs and SNRIs. It is less common with TCAs except maybe clomipramine. Switching to another SSRI like citalopram, or escitalopram is an option worth considering if the GP won't prescribe buspirone, however, there are no guarantees.
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    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

  5. #5
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    Re: Sertraline: from 100mg to 50mg

    I’ve discussed it with the GP, he’s not keen on prescribing more than a week’s supply of buspirone at a time. So I’m trying to reduce the dose to see if it helps.

  6. #6
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    Re: Sertraline: from 100mg to 50mg

    Quote Originally Posted by USER12 View Post
    I’ve discussed it with the GP, he’s not keen on prescribing more than a week’s supply of buspirone at a time.
    Sigh! Did he offer an explanation for his lack of enthusiasm?
    __________________
    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

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