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Thread: Doctor just upped my promazine.

  1. #11
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    Re: Doctor just upped my promazine.

    Quote Originally Posted by NoraB View Post
    That's what I say to Hubs each night as I sharpen up the garden spade...


    He sleeps with one eye open.
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  2. #12
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    Re: Doctor just upped my promazine.

    Quote Originally Posted by panic_down_under View Post
    The increased dose will take a week or more to become fully effective, James, and the withdrawal won't have helped.
    True. But I'm not sure how it's going to help me. I woke up today with racing thoughts. My body was calm but my thoughts were coming in at a million miles per hour. Still got it now, but it's not as bad.

    Quote Originally Posted by panic_down_under View Post
    How much paroxetine are you taking now and how long have you been at that dose?
    10mg at 8am.
    10mg at 12pm.
    10mg at 4pm.
    10mg at 8pm.
    20mg at bed time.

    Quote Originally Posted by panic_down_under View Post
    Agreed. However, I think you could be doing better than you are.
    I agree.
    Quote Originally Posted by panic_down_under View Post
    Which should never be allowed to happen. I wonder how many with cancer, or heart disease would be left to drift in limbo like this. I suspect not many.

    I may be wrong, but from this distance the NHS's big structural failing seems to be how few options patients have in choosing their doctors. If I'm not happy with my GP I can just make an appointment with another at any time. If I have a mind to, and deep enough pockets to cover any copayments and other expenses, there is nothing stopping me from consulting every GP in the land. There are more restrictions on specialists, but even then there are always options.
    Yeah this is the problem. I have a new doctor who has spent a long time working in mental health. It would have made sense to put me with her 4 years ago when I joined the surgery. I don't think she's working at the moment when I ask to speak to her she's not in the office. I need a face to face with her by my surgery is being very pro-active and keeping it's doors closed for the most part.

    It's been a mess long before COVID though. If somebody is known to be mentally unwell, and is known to be on the wrong medications (their words), and is known to be still struggling then why on earth would they kick you off their system because you physically can't attend an appointment? The jackasses had been visiting my home for weeks and knew I was agoraphobic.

    Once I told them I smoked cannabis they upped and left.

    I don't smoke cannabis anymore. I may have the odd joint on a weekend but I don't use it for my mental health anymore. I'd love to, but at the moment I am doing what they want me to do so they can't just walk out and leave me hanging in the system. I don't smoke it now, thus they can't use that against me.

    It does seem like I'm out of the frying pan into the fire. Increase in meds along the line. I'm actually worse now because the cannabis slowed my thoughts. My liver is looking forward to being bombarded with more medications.
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  3. #13
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    Re: Doctor just upped my promazine.

    Quote Originally Posted by WiredIncorrectly View Post
    True. But I'm not sure how it's going to help me. I woke up today with racing thoughts. My body was calm but my thoughts were coming in at a million miles per hour. Still got it now, but it's not as bad.
    If it is still not doing much after 7-10 days then your GP may need to either raise the dose, it is on the low side, or consider prescribing something else.


    10mg at 8am.
    10mg at 12pm.
    10mg at 4pm.
    10mg at 8pm.
    20mg at bed time.
    That is very odd. Paroxetine has a short half-life and no active metabolite so there is a strong case for splitting the dose of immediate-release paroxetine taking half about 12 hours apart, and I would argue that it's no a bad idea with the slow-release formulations too, however, I don't understand what they're trying to achieve with this. All this does is increase the risk of missing doses.

    I need a face to face with her by my surgery is being very pro-active and keeping it's doors closed for the most part.
    Which given the times is good...up to a point. There are circumstances that need face to face time and you're in that situation, imho.

    Once I told them I smoked cannabis they upped and left.

    I don't smoke cannabis anymore. I may have the odd joint on a weekend but I don't use it for my mental health anymore. I'd love to, but at the moment I am doing what they want me to do so they can't just walk out and leave me hanging in the system. I don't smoke it now, thus they can't use that against me.
    I can understand that attitude a decade, or two ago, but these days?! It's not like you're the only one so they need to deal with it just like every other factor affecting their patients, not running away and hiding. It is part of their frigging job for sake!! Sigh!

    What they should have done is explain that THC undoes the positive effects of the meds you're taking, especially the paroxetine, so while it may be calming for a while it is actually making things worse. CBD is a far better option if you need something, though I'm not advocating it. You've got more than enough chemicals 'entertaining' your liver as it is, and the more psychoactives taken the harder it becomes to determine what they are all doing.
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  4. #14
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    Re: Doctor just upped my promazine.

    Quote Originally Posted by panic_down_under View Post
    If it is still not doing much after 7-10 days then your GP may need to either raise the dose, it is on the low side, or consider prescribing something else.




    That is very odd. Paroxetine has a short half-life and no active metabolite so there is a strong case for splitting the dose of immediate-release paroxetine taking half about 12 hours apart, and I would argue that it's no a bad idea with the slow-release formulations too, however, I don't understand what they're trying to achieve with this. All this does is increase the risk of missing doses.



    Which given the times is good...up to a point. There are circumstances that need face to face time and you're in that situation, imho.



    I can understand that attitude a decade, or two ago, but these days?! It's not like you're the only one so they need to deal with it just like every other factor affecting their patients, not running away and hiding. It is part of their frigging job for sake!! Sigh!

    What they should have done is explain that THC undoes the positive effects of the meds you're taking, especially the paroxetine, so while it may be calming for a while it is actually making things worse. CBD is a far better option if you need something, though I'm not advocating it. You've got more than enough chemicals 'entertaining' your liver as it is, and the more psychoactives taken the harder it becomes to determine what they are all doing.
    You're quite knowledgeable PDU and very helpful. I didn't understand the THC causing problems until I researched about a month ago. I'm not expert, buts something to with dopamine receptors being blocked by the medications, but at the same time stimulated by the THC. Can't tell you how true/false it was. I'll dig up the article.

    Thanks matey.
    __________________
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    “I would rather have questions that can't be answered than answers that can't be questioned.” - Richard Feynman

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  5. #15
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    Re: Doctor just upped my promazine.

    Quote Originally Posted by WiredIncorrectly View Post
    I'm not expert, buts something to with dopamine receptors being blocked by the medications, but at the same time stimulated by the THC. Can't tell you how true/false it was. I'll dig up the article.
    THC has a range of effects on neurotransmitter systems, none of them good, James. But in terms of anxiety and depression the problem is it defragments the DNA of hippocampal neurons killing them which causes the hippocampi to atrophy (Ameri A, 1999; Chan GC, 1998 abstract | full text; Yucel M, 2008; Lorenzetti V, 2016). This is similar to the hippocampal damage caused by the stress hormone cortisol which is thought to trigger and sustain anxiety disorders and depression.

    CBD seems to protect brain cells from the damage, however, over the years growers have been selecting stains with ever higher concentrations of THC at the expense of CBD. The pot I first encountered back in the 1960s was fairly harmless even to those with pre-existing anxiety disorders, arguably much less destructive than alcohol which also nukes the hippocampi, but that's hasn't been the case for quite a while.
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    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

  6. #16
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    Re: Doctor just upped my promazine.

    I hear what you're saying PDU. What perplexes me is if THC is no good, why is it prescribed in the US for mental health conditions? I'm not in full agreement that THC is no good. But, I'm not saying THC is a solution either. The pills, and the green stuff, are going to do me no good. Ideally I'd rather have to use nothing. No meds. No smoke. It's really hard to get to that point from where I am now. I've tried lots of different CBD's but as I'm THC free (mostly) I will retry the capsules.

    Btw, if you're talking of street cannabis being no good, in comparison to professional growers (in the USA and Amsterdam), then yes absolute agreement. Street growers don't flush and they pump the plant full of chemical nutes to get bigger harvests. The high from them includes chemicals which are damned right dangerous IMHO and the chemicals should be banned from sale.

    Since I quit my ectopic heartbeats are crazy. Had a nasty attack of them today that threw me off. I had a few puffs and my anxiety and ectopics are gone. Strange huh?

    Thanks for the discussion Hope everything is well where you are PDU. Is your country a part of the British Empire? Do you have the same Queen?

    Bravo on your signature list too! As I'm a programmer, I really enjoyed that bots article.
    Last edited by WiredIncorrectly; 15-11-20 at 16:49.
    __________________
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    “I would rather have questions that can't be answered than answers that can't be questioned.” - Richard Feynman

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  7. #17
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    Re: Doctor just upped my promazine.

    Quote Originally Posted by WiredIncorrectly View Post
    I hear what you're saying PDU. What perplexes me is if THC is no good, why is it prescribed in the US for mental health conditions?
    They also prescribe opiates by the truck load in many places too. The American Psychiatric Association is not a fan - PDF.

    Btw, if you're talking of street cannabis being no good, in comparison to professional growers (in the USA and Amsterdam), then yes absolute agreement. Street growers don't flush and they pump the plant full of chemical nutes to get bigger harvests. The high from them includes chemicals which are damned right dangerous IMHO and the chemicals should be banned from sale.
    Are the growers in the USA and Amsterdam really that much better? I don't know about the Netherlands, but I have seen documentaries on legal cannabis in the States and while there seems to be some very professional companies producing it, there are still dubious actors in the business. There doesn't seem to be much regulatory oversight either.

    Since I quit my ectopic heartbeats are crazy. Had a nasty attack of them today that threw me off. I had a few puffs and my anxiety and ectopics are gone. Strange huh?
    No, not strange, James. The brain has significant control over cardiovascular function, as does the enteric nervous system, the mini brain that controls the gut which is also directly linked to the heart and lungs. Somewhere in my collection of videos is one showing the large blood vessels connected to the heart going into spasms during a panic attack. Taking a magnesium supplement might help.

    Is your country a part of the British Empire? Do you have the same Queen?
    Yes, well Commonwealth, and yes. Betty Windsor was my boss for 33 years. Met her a couple of times and had an animated discussion with the Duke during one of them which I think delayed proceedings. Might have cost me a knighthood for keeping her waiting...at least that's my excuse.

    As I'm a programmer, I really enjoyed that bots article.
    The Net has been a boon for humanity putting all our accumulated knowledge at our finger tips, but it has a dark side too.
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    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

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