Re: Well here we go... 150mg
Originally Posted by
Paradise10
Had to go get some Nexium at lunch time as this burping, stomach ache and uncomfortable feeling in my chest is driving me nuts, not sure It's done much good though. It said in the leaflet with it that you can't take it with Citalopram or Imaprime (or whatever It's called) or Diazepam, never said Venlafaxine
Nexium (esomeprazole) slows the rate at which citalopram, imipramine and diazepam are metabolized which may increase their blood levels. That could be an issue with citalopram at its maximum dose, less so with the other two. Esomeprazole has a very short half-life, about 80 minutes so even with citalopram this is unlikely to be a significant problem with a single dose, but taking esomeprazole regularly for some days might raise citalopram plasma levels enough to trigger side-effects.
I might also look to reduce and come off the nortryptline after Christmas too as I'm not sure that's even doing anything.
Probably a good idea, although there is a chance it is having a positive effect, Ava. In the days before SNRIs were readily available nortriptyline was sometimes prescribed with a SSRI, usually sertraline, to create a bespoke SNRI. Many of the old time psychiatrists still prefer this to prescribing SNRIs because their short half-lives often creates both severe initial side-effects and withdrawals. I'd also wait until the side-effects you're currently experiencing settle down so there is less risk of confusion between them and any withdrawal symptoms from discontinuing the nortriptyline. Withdrawal from TCAs is usually less severe than from SSRIs/SNRIs, but there are always exception to prove the rule, so... I'd cut back in two stages dropping the dose to 10mg for two weeks.
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The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.