Increasing Venlafaxine to 300mg

[panic_down_under]

What other problems do you foresee?

Nothing specific, just that there are better meds for the creation of bespoke SNRIs. Sertraline was old timers preferred serotonergic AD for this because of fewer drug-drug interactions and any of the SSRIs except maybe paroxetine would be easier to quit than venlafaxine.