Re: Increasing Venlafaxine to 300mg
Originally Posted by
Cornish Andy
I was lucky to get a psychiatrist appointment, and she has recommended increasing the Venlafaxine to 300mg. Now, I know 225mg is considered the maximum dose for anxiety and panic, but 300mg or higher can be given for clinical depression. At higher doses I also know the drug behaves differently and can increase adrenaline.
Although venlafaxine is classified as a SNRI it is really only a SSRI, Andy. It only begins to inhibit noradrenaline (NA), aka norepinephrine, reuptake at around 225mg/day, but even at the maximum recommended 375mg/day the NA inhibition is still weak. It doesn't increase adrenaline release. Several SSRIs actually inhibit NA reuptake more strongly than venlafaxine does, albeit still only moderately compared to other SNRIs and some TCAs.
How is this going to make me feel? Could this make my anxiety/panic worse? Will I feel even more spaced out and drugged up at this dose?
You'll probably feel not much different once any side-effects triggered by the dose increase subside.
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The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.