I've only ever had one virus in 25 years online, and that was a 'drive-by' on an e-card site my late wife visited thanks to the dreaded security hole that was ActiveX; I've forgotten the name of it but it involved some very specific software to get rid of it. Some of my friends have picked up ransomware - usually because the libidinous twerps have been looking at porn. You're right - Windows Defender is more than up to the job.
Now, I have always used motherboards from MSI in all the PCs I have ever built and they are brilliant. I can only imagine their laptops would be as good.
That looks a good buy to me.