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Thread: Lofepramine to sertraline

  1. #1
    Join Date
    Oct 2016
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    Lofepramine to sertraline

    Hi , I’ve been on 70mg of lofepramine in the morning and 140 at night for a couple of years now but I’m getting switched back on to sertraline, gradually lowering the dose of lofepramine before starting a low dose of sertraline until fully switched . Well it seems like it would be easier just to do a straight swap and put up with some side effects/ withdrawals for a few days? Had anyone done this before and how did it go?

  2. #2
    Join Date
    Jan 2017
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    3,555

    Re: Lofepramine to sertraline

    Quote Originally Posted by Shezney View Post
    Hi , I’ve been on 70mg of lofepramine in the morning and 140 at night for a couple of years now but I’m getting switched back on to sertraline,
    Because lofepramine has stopped working?

    gradually lowering the dose of lofepramine before starting a low dose of sertraline until fully switched . Well it seems like it would be easier just to do a straight swap and put up with some side effects/ withdrawals for a few days? Had anyone done this before and how did it go?
    Lofepramine and sertraline affect different receptor and transporter systems so cross tapering over a couple of weeks is usually the better, and maybe safer, option.
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