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Thread: Started Trazodone

  1. #1
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    Started Trazodone

    Hi All,

    I have just started trazodone 50mg and was expecting it to help with anxiety. however i think its making my anxiety worse. I'm also on 60mg of clomipramine, just come down from 120 3 days ago. I also take 15mg of olanzapine for anxiety

    anyone on this med id greatly appreciate some encouragement.

    Very frightened Paul

  2. #2
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    Re: Started Trazodone

    Quote Originally Posted by Sober2000june View Post
    I have just started trazodone 50mg and was expecting it to help with anxiety. however i think its making my anxiety worse.
    It is unlikely to have a positive effect that quickly, or at that dose, Paul. Trazodone only begins to act as an antidepressant at doses around 200mg and most need to take at least 300mg for optimum results. As with all ADs kick-in typically takes 4-12 weeks at a therapeutic dose.

    I'm also on 60mg of clomipramine, just come down from 120 3 days ago. I also take 15mg of olanzapine for anxiety
    The clomipramine dose reduction could be contributing to the increased anxiety especially given the large dose drop. Was 120mg the most you took and how long were you on it?
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  3. #3
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    Re: Started Trazodone

    120mg was the highest i took. i was on the med 7 months laterly 90, 100 then 120 mg. It was makeing me worse i had no energy to do anything but it still didn't help with anxiety.

    Im now on 75mg of trazodone as i suspected this is the dose for anxiety.

    just trying to get through the days.

    Itd be good if anyone whose on it to chime in.

    Kind wishes Paul

  4. #4
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    Re: Started Trazodone

    Quote Originally Posted by Sober2000june View Post
    m now on 75mg of trazodone as i suspected this is the dose for anxiety.
    As per above, trazodone only begins to act as an antidepressant at around 200mg/day, but it may ease anxiety at lower doses by sedation, Paul.

    Itd be good if anyone whose on it to chime in.
    Trazodone is mostly only prescribed for SSRI induced insomnia, not anxiety/depression, these days which is a pity, imo, and even then not that often in the UK as GPs there seem to prefer mirtazapine. Stephen Stahl's Mechanism of Action of Trazodone: a Multifunctional Drug (PDF) might be of interest.
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    The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.

  5. #5
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    Re: Started Trazodone

    hoping it works for anxiety soon as my anxiety is off the chart.

  6. #6
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    Re: Started Trazodone

    Been really hard, psych has upped my dose to 150mg start tonight. Some positive feedback would greatly be appreciated

  7. #7
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    Re: Started Trazodone

    Quote Originally Posted by Sober2000june View Post
    Been really hard, psych has upped my dose to 150mg start tonight. Some positive feedback would greatly be appreciated
    That's good as it brings you near to the minimum therapeutic dose which is usually somewhere in the 150-225mg/day range.
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  8. #8
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    Re: Started Trazodone

    How did the medication work out for you after upping the does?

    I hope all is well.
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