All-over itching when I stop taking it

[olivia0703]

Every time I stop taking Lyrica, I get intense itching that keeps me awake at night. Anyone else experience this?

[panic_down_under]

Itching is a relatively common pregabalin (Lyrica) withdrawal symptom. It is usually short lived typically diminishing within a week, but it can linger in some. Over-the-counter antihistamines can significantly ease it, as may magnesium supplements. Many antihistamines are sedating which will also help in getting a good night's sleep. Talk to your chemist about which antihistamine is likely to be the most effective.

[olivia0703]

Ah, thank you! What is the mechanism that causes the itching? Nerve endings getting hyperexcitable?

[panic_down_under]

Yes. Pregabalin dampens nerve ending which is why it is often prescribed to treat diabetes triggered nerve pain (diabetes neuropathy). When it is stopped there can be a rebound as the nerves readjust to the loss of the med.

[olivia0703]

Thanks! You are so incredibly helpful

[olivia0703]

Does withdrawal from this drug also cause a massive uptick in anxiety?

[panic_down_under]

If you'd been taking it for months, maybe. But after only a week on it, no. Are you taking anything else?

[olivia0703]

No, just 7.5mg mirtazapine at night that I've been taking for years

[olivia0703]

But the itching? It happens every time I stop, even if I've only been taking it 4/5 days

[panic_down_under]

That's unusual. Have you tried an antihistamine and/or a magnesium supplement, Olivia?