Re: Zoloft and Wellbutrin fear of Long Qt

Originally Posted by
Deepseathree
However, I'm worried about the potential impact of taking both Wellbutrin and Zoloft on my QT interval. Although my previous EKGs were normal, 'Dr. Google' has made me anxious about the possible risks
Bupropion (Wellbutrin) doesn't affect the QT interval and it is only an issue with sertraline (Zoloft) when it is taken with other medications known to increase the risk. CredibleMeds maintains a searchable register of meds which impact the heart's electrical system on behalf of the FDA (free registration is required to view the data) if you wish more information.
The only significant interaction between these ADs is that buproprion slows the rate at which sertraline is metabolized which may increase its blood plasma levels. This is likely to only be a problem at near the recommended maximum dose of 200mg/day. However, it may increase the severity of any initial side-effects to some degree so it might be better to start on only 25mg for the first week, however, please discuss this with the prescribing doctor before altering the prescribed dose as there may be factors I'm not aware of.
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The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.