Re: Sertraline - thoughts appreciated

Originally Posted by
AMG123
I've been on sertraline for a week and I have so many side effects:
Am I right in thinking you've been prescribed 50mg sertraline?
- headaches
- muscle tension
- jaw pain
- exhaustion (insane exhaustion!)
- a little nausea
- struggling to focus/concentrate
Is this normal?
These are all potential initial side-effects.
Serotonin is not only a brain neurotransmitter. It has many functions throughout the body. Nor is the brain the most serotonergic organ so some of them may be more affected by the initial increase in serotonin activity than the brain.
The common pain killers should lessen the headaches and muscle pains. As SSRIs are mild anticoagulants paracetamol, aka acetaminophen, is a better option than aspirin and ibuprofen, etc, if you need to take them for more than a day. Ginger and/or vitamin B6 should ease the nausea.
Am I always going to feel this awful? Just looking for advice and people who might make me feel a bit better!
Bio-feedback mechanisms typically begin down-regulating serotonin synthesis and expression within a week or two which should see most of these side-effects begin to diminish, however, they may return for a while after dose increases although usually at a lesser intensity.
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The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.