Hi JT69. All I can say I am afraid is that it wasn't til day 46 until the effects wore off for me and Im not sure if they were withdrawal from the citalopram or side effects of the mirtazapine. Looking back I don't know how I coped for so long but I did. Where I am now is I have good days and bad. If I eat healthy and exercise combined with the mirt its more good days. I am not sure long term if I can stay on it though as I believe my problems need to be tackled via diet (i am having a blood test tomorrow for various things). At the moment though, to get me through my holiday I will stay with the mirt. I have put on 10 pounds in weight since I started the mirt despite exercising and eating better (at the start I did eat naughty things I have to admit) That really bothers me. I do not crave sweet things as much now though, thats wearing off if thats any comfort. I don't know anything about odema. You definately need to consult doc bout that. I still find I have bouts of anger with this drug too and it is like a sleeping tablet when I go to bed even after this length of time taking it! Don't know how I am going to deal with this on holiday?I still feel its early days for you to expect effects to be completely gone but if you do find it unbearable then its up to you whether you continue or not. Only you can decide. If you take something esle you may have to start all over again with the side effects. Have you thought about that? Don't let the doc push you into anything you don't want to do though. Its your body! Good luck.