Hey ya , i started on zispen 15 and worked my way up to 45mg , i had never taking anything like that before cos im a single parent of 3 young kids , i was always weary of stuff that wud make ya drozy , anyway yes i experienced them symptoms for the first month of taking the 45mg but in hindsight it was the best decision of my life to continue taking them. i now feel motivated in life where i never used to be and to be honest i didnt even no how bad my depression was until i was out the far side of it. i started them simply to help me sleep. i say take them for 6 weeks and if u dont feel the benifit after that then reduce ur dose again. hope i have helped