Hi, I would love to hear from anyone who has found that the older tricyclics--specifically Clomipramine and Lofepramine--have a marked effect on their symptoms, while many of the SSRI-group medications are either ineffective or only work on some aspects of the condition. I know Clomipramine, in particular, has intolerable side effects for many people, but what I am most interested in is its effects on intrusive thoughts, guilt and anxiety, especially social anxiety. I've found in my own case that SSRIs had no effect on these sorts of symptoms in particular and am wondering if this is a general experience.