I took my first dose of duloxetine last night 60mg. It was odd because I was just waiting to feel panicky but nothing. I woke several times in the night but this was because I felt nauseous. I had actually woken up at 11.30, 2am and then again about 5.30am so not a good night. This morning was very difficut and I nearly didn't make it in to work. I felt really sick and giddy and went back to lie on the bed. Again I felt ill at the bus stop but made it into work. I hope things improve tomorrow. I think that it is doubly difficult as I am to stay on the prothiaden until I am used to the duloxetine and then reduce the prothiaden. I will let you know how I get on.