Hi, I've been on fluxotine for about three years, mostly at 20mg with about a year at 40mg. Things were going ok so dropped to 20mg, until recently when the anxiety reared it's ugly head again, sure enough the depression soon followed. I am pretty sure the low feelings are caused by the anxiety spells. I have re-upped my dose to 40mg on Sunday and will see how that goes. Early symptom could be increased anxiety but not sure as it wa bad before anyway. My question is if fluxotine has stopped working on me does that mean the ssri's are no longer an option or has anyone successfully transferred from one ssri to another after a long spell of 2 years or more?